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2015
4-Hydroxybenzyl methyl ether improves learning and memory in mice via the activation of dopamine D1 receptor signaling
Authors: Lee, H.E., Lee Y.W., Park S.J., Jeon S.J., Kim E., Lee S., Han A.-R., Seo E.-K., Ryu J.H. 4-Hydroxybenzyl methyl ether by Gastrodia elata Blume on passive avoidance acquisition, consolidation and retrieval in mice: dopaminergic modulation
Lee, H.E., Lee Y.W., Park S.J., Jeon S.J., Kim E., Lee S., Han A.-R., Seo E.-K., Ryu J.H. - 2015
Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels
Authors: Liang, C., Tan S., Huang Q., Lin J., Lu Z., Lin X. Pratensein on Morris water maze performance, passive avoidance impairment, neuronal degeneration and brain derived neurotrophic factor levels by intra-hippocampal Sβ1-42 peptide injection in rats
Liang, C., Tan S., Huang Q., Lin J., Lu Z., Lin X. - 2015
Ameliorative effect of gastrodin on 3,3'-iminodipropionitrile-induced memory impairment in rats
Authors: Wang, X., Tan Y., Zhang F. Gastrodin on 3-3'iminodipropionitrile-induced hippocampal serotonin level/expression and passive avoidance impairment in rats
Wang, X., Tan Y., Zhang F. - 2015
1-Aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats
Authors: Popik, P., Holuj M., Nikiforuk A., Kos T., Trullas R., Skolnick P. NMDA glycine antagonist 1-aminocyclopropanecarboxylic acid on active avoidance, object recognition, prepulse inhibition of startle reflex and operant conditioning in control and ketamine/phencyclidine-treated rats
Popik, P., Holuj M., Nikiforuk A., Kos T., Trullas R., Skolnick P. - 2015
Salidroside ameliorates cognitive impairment in a D-galactose-induced rat model of Alzheimer's disease
Authors: Gao, J., He H., Jiang W., Chang X., Zhu L., Luo F., Zhou R., Ma C., Yan T. Salidroside on D-galactose-induced Morris water maze and passive avoidance impairment of rats: hippocampal pro-inflammatory cytokine levels
Gao, J., He H., Jiang W., Chang X., Zhu L., Luo F., Zhou R., Ma C., Yan T. - 2015
Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain
Authors: Li, J.-J., Zhu Q., Lu Y.-P., Zhao P., Feng Z.-B., Qian Z.-M., Zhu L. Ligustilide on D-galactose-induced neurotoxicity and Morris water maze impairment in mice
Li, J.-J., Zhu Q., Lu Y.-P., Zhao P., Feng Z.-B., Qian Z.-M., Zhu L. - 2015
Cilostazol but not sildenafil prevents memory impairment after chronic cerebral hypoperfusion in middle-aged rats
Authors: Godinho, J., de Oliveira J.N., Dias Fiuza Ferreira E., Zaghi G.G.D., Bacarin C.C., de Oliveira R.M.W., Milani H. Cilostazol and sildenafil on hippocampal and cortical neuron damage and aversive spatial learning deficit by chronic cerebral ischemia in middle-aged rats
Godinho, J., de Oliveira J.N., Dias Fiuza Ferreira E., Zaghi G.G.D., Bacarin C.C., de Oliveira R.M.W., Milani H. - 2015
Protective effects of baicalin on Aβ1-42-induced learning and memory deficit, oxidative stress, and apoptosis in rat
Authors: Ding, H., Wang H., Zhao Y., Sun D., Zhai X. Baicalin on intra-hippocampal Aβ1-42-induced neurotoxicity and Morris water maze deficit in rats
Ding, H., Wang H., Zhao Y., Sun D., Zhai X. - 2015
Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: positive clue toward sad
Authors: Moorthi, P., Premkumar P., Priyanka R., Jayachandran K.S., Anusuyadevi M. Resveratrol on spatial learning and hippocampal, amygdalar and cortical neuron loss in young and aged rats
Moorthi, P., Premkumar P., Priyanka R., Jayachandran K.S., Anusuyadevi M. - 2015
Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats
Authors: Han, H., Qian Q., Yu Y., Zhao D., Sun G. Antiepileptic lamotrigine on ischemia-induced hippocampal injury and Morris water maze impairment in rats
Han, H., Qian Q., Yu Y., Zhao D., Sun G. - 2015
PDE5 inhibition improves acquisition processes after learning via a central mechanism
Authors: Akkerman, S., Blokland A., van Goethem N.P., Cremers P., Shaffer C.L., Osgood S.M., Steinbusch H.W.M., Prickaerts J. Intracerebroventricular or oral vardenafil on scopolamine-induced object recognition impairment in rats
Akkerman, S., Blokland A., van Goethem N.P., Cremers P., Shaffer C.L., Osgood S.M., Steinbusch H.W.M., Prickaerts J. - 2015
Harmine treatment enhances short-term memory in old rats: dissociation of cognition and the ability to perform the procedural requirements of maze testing
Authors: Mennenga, S.E., Gerson J.E., Dunckley T., Bimonte-Nelson H.A. Harmine on spatial learning in old rats
Mennenga, S.E., Gerson J.E., Dunckley T., Bimonte-Nelson H.A. - 2015
Differential effects of quercetin on hippocampus-dependent learning and memory in mice fed with different diets related with oxidative stress
Authors: Xia, S.-F., Xie Z.-X., Qiao Y., Li L.-R., Cheng X.-R., Tang X., Shi Y.-H., Le G.-W. Quercetin on high-fat diet dependent spatial learnming impairment and hippocampal oxidative stress biomarker gene expression in mice
Xia, S.-F., Xie Z.-X., Qiao Y., Li L.-R., Cheng X.-R., Tang X., Shi Y.-H., Le G.-W. - 2015
Non-selective NSAIDs improve the amyloid-β-mediated suppression of memory and synaptic plasticity
Authors: Mohammadpour, J.D., Hosseinmardi N., Janahmadi M., Fathollahi Y., Motamedi F., Rohampour K. Aspirin and sodium salicilate on amyloid-β, Morris water maze and hippocampal neuron excitability impairment in rats
Mohammadpour, J.D., Hosseinmardi N., Janahmadi M., Fathollahi Y., Motamedi F., Rohampour K. - 2015
Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease
Authors: Wang, L:, Kang H., Li Y., Shui Y. Yamamoto R., Sugai T., Kato N. BK channel activator isopiranic acid on hippocampal neuron excitability, Morris water maze and object recognition in 3XTg and control mice
Wang, L:, Kang H., Li Y., Shui Y. Yamamoto R., Sugai T., Kato N. - 2015
Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway
Authors: Yin, Z., Yu H., Chen S., Ma C., Ma X., Xu L., Ma Z., Qu R., Ma S. Asiaticoside on diabets-induced Morris water maze and hippocampal plasticity impairment in rats: effects on oxidative stress and phosphoinositide 3-kinase/protein kinase B(AKT)/nuclear factor-kappa B pathway
Yin, Z., Yu H., Chen S., Ma C., Ma X., Xu L., Ma Z., Qu R., Ma S. - 2015
Activation of hippocampal CREB by rolipram partially recovers balance between TNF-α and IL-10 levels and improves cognitive deficits in diabetic rats
Authors: Miao, Y., He T., Zhu Y., Li W., Wang B., Zhong Y. Rolipram on Morris water maze and hippocampal CREB/interleukin-10 expression impairment induced by streptozotocin, in diabetic rats
Miao, Y., He T., Zhu Y., Li W., Wang B., Zhong Y. - 2015
Gracilins: spongionella-derived promising compunds for Alzheimer disease
Authors: Leiros, M., Alonso E., Rateb M.E., Houssen W.E., Ebel R., Jaspars M., Alfonso A., Botana L.M. Diterpenoid gracilins on neuroprotection and Morris water maze performance in 3XTg-AD and control mice
Leiros, M., Alonso E., Rateb M.E., Houssen W.E., Ebel R., Jaspars M., Alfonso A., Botana L.M. - 2015
Beneficial behavioral, neurochemical and molecular effects of 1-(R)-aminoindan in aged mice
Authors: Badinter, F., Amit T., Bar-Am O., Youdim M.B.H., Weinreb O. 1-(R)-aminoindan on Morris water maze performance, object recognition, response to stress, nest building test, hippocampal, striatal brain-derived neurotrophic factor/nerve growth factor/bel2 protein levels and striatal dopamine/morepinephrine/serotonin levels in adult and aged mice
Badinter, F., Amit T., Bar-Am O., Youdim M.B.H., Weinreb O. - 2015
Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice
Authors: Li, C., Zug C., Qu H., Schluesener H., Zhang Z. Hesperidin on hippocampal and cortical β-amyloid-dependent social interaction deficit in mice
Li, C., Zug C., Qu H., Schluesener H., Zhang Z. - 2015
Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse
Authors: Taniguchi, S., Kuwahara M., Ito K. N-acetyl-D-mannosamine on hippocampal long-term potentiation in SAMP8 and control mice of different age
Taniguchi, S., Kuwahara M., Ito K. - 2015
Chronic treatment with ginsenoside Rg1 promotes memory and hippocampal long-term potentiation in middle-aged mice
Authors: Zhu, G., Wang Y., Li J., Wang J. Ginsenoside Rg1 on fear conditioning and hippocampal long-term potentiation, excitability and plasticity in middle-aged mice
Zhu, G., Wang Y., Li J., Wang J. - 2015
Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways
Authors: Zhu, G., Liu Y., Wang Y., Bi X., Baudry M. Calpain-1 on hippocampal neuron excitability/plasticity and fear conditioning in mice: protein kinase and phosphodiesterase-4 modulation
Zhu, G., Liu Y., Wang Y., Bi X., Baudry M. - 2015
Colivelin ameliorates amygdaloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats
Authors: Wu, M.-N., Zhou L.-W., Wang Z.-J., Han W.-N., Zhang J., Liu X.-J., Tong J.-Q., Qi J.-S. Peptide colivelin on amyloid-β spatial learning and hippocampal excitability impairment in rats
Wu, M.-N., Zhou L.-W., Wang Z.-J., Han W.-N., Zhang J., Liu X.-J., Tong J.-Q., Qi J.-S. - 2015
MRZ-99030 - a novel modulator of Aβ aggregation: II - Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice
Authors: Rammes, G., Gravius A., Ruitenberg M., Wegener N., Chambon C., Sroka-Saidi K., Jeggo R., Staniaszek L., Spanswick D., O'Hare E., Palmer P., Kim E.-M., Bywalez W., Egger V., Parsons C.G. Dipeptide MR2-99030 on intracerebroventricular Aβ amyloid1-42 hippocampal long-term potentiation and novel object recognition impairment in rodents
Rammes, G., Gravius A., Ruitenberg M., Wegener N., Chambon C., Sroka-Saidi K., Jeggo R., Staniaszek L., Spanswick D., O'Hare E., Palmer P., Kim E.-M., Bywalez W., Egger V., Parsons C.G. - 2015
Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors
Authors: Bollen, E., Akkerman S., Puzzo D., Gulisano W., Palmeri A., D'Hooge R., Balschun D., Steinbusch H.W.M., Blokland A., Prickaerts J. Phosphodiesterase inhibitors on hippocampal long-term potentiation and object memory in rats
Bollen, E., Akkerman S., Puzzo D., Gulisano W., Palmeri A., D'Hooge R., Balschun D., Steinbusch H.W.M., Blokland A., Prickaerts J. - 2015
Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings
Authors: Gualtieri, F.2014
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice
Authors: Grizzell, J.A., Iarkov A., Holmes R., Mori T., Echeverria V. Cotinine on response to stress, spatial learning, locomotor activity and hippocampal/prefrontal/entorhinal plasticity in mice
Grizzell, J.A., Iarkov A., Holmes R., Mori T., Echeverria V. - 2014
Anti-amnesic effect of alkaloid fraction from Lycopodiella cernua (L.) Pic. Serm. on scopolamine-induced memory impairment in mice
Authors: Chuong, N.N., Trung B.H., Luan T.C., Hung T.M., Dang N.H., Dat N.T. Lycopodiella cernua extract on learning impairment by scopolamine in mice
Chuong, N.N., Trung B.H., Luan T.C., Hung T.M., Dang N.H., Dat N.T. - 2014
Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: possible involvement of the acetylcholinesterase and N+,K+-ATPase activities
Authors: Abdalla, F.H., Schmatz R., Cardoso A.M., Carvalho F. B., Baldissarelli J., de Oliveira J.S., Rosa M.M., Nunes M.A.G., Rubin M.A., da Cruz I.B.M., Barbisan F., Dressler V.L., Pereira L.B., Schetinger M.R.C., Morsch V.M., Goncalves J.F., Mazzanti C.M. Quercetin on passive avoidance learning, exploratory activity and brain acetylcholinesterase in control and exposed to cadmium rats
Abdalla, F.H., Schmatz R., Cardoso A.M., Carvalho F. B., Baldissarelli J., de Oliveira J.S., Rosa M.M., Nunes M.A.G., Rubin M.A., da Cruz I.B.M., Barbisan F., Dressler V.L., Pereira L.B., Schetinger M.R.C., Morsch V.M., Goncalves J.F., Mazzanti C.M. - 2014