2014

Contained in: Hippocampus, 2014: 24, 270-279

Early age-dependent impairments of context-dependent extinction learning, object recognition, and object-place learning occur in rats

Authors: Wiescholleck, V., Andrè M.A.E., Manahan-Vaughan D.

  Spatial memory extinction, object location/recognition and locomotion/exploration in young and aged rats
  Wiescholleck, V., Andrè M.A.E., Manahan-Vaughan D. - 2014

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   AGE   EXTINCTION
Contained in: Psychopharmacology, 2014: 231, 863-874

MDMA enhances hippocampal-dependent learning and memory under restrictive conditions, and modifies hippocampal spine density

Authors: Abad, S., Fole A., del Olmo N., Pubill D., Pallas M., Junyent F., Camarasa J., Camins A., Escubedo E.

  Ecstasy on spatial learning, object recognition, exploratory activity, response to stress, hippocampal plasticity and brain derived neurotrophic factor expression in rats
  Abad, S., Fole A., del Olmo N., Pubill D., Pallas M., Junyent F., Camarasa J., Camins A., Escubedo E. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   DOPAMINE   HIPPOCAMPUS, FORNIX AND SUBICULUM   NEUROTROPHIC FACTORS   NEUROGENESIS AND PLASTICITY   SEROTONIN   STRESS
Contained in: Behav. Brain Res., 2014: 265, 111-120

Protein tyrosine phosphatase receptor type R deficient mice exhibit increased exploration in a new environment and impaired novel object recognition memory

Authors: Erkens, M., Bakker B., van Duijn L.M., Hendriks W.J.A.J., Van der Zee C.E.E.M.

  Protein tyrosine phosphatase receptor on locomotion/exploration, circadian activity, fear conditioning, object recognition and Morris water maze performance in mice
  Erkens, M., Bakker B., van Duijn L.M., Hendriks W.J.A.J., Van der Zee C.E.E.M. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   EXTINCTION   FEAR AND RELATED BEHAVIORS   SMELL   PROTEIN KINASES   CIRCADIAN RHYTHMS   PROTEINS AND GENES
Contained in: Cell. Mol. Neurobiol., 2014: 34, 333-342

Bisphenol A does not affect memory performance in adult male rats

Authors: Kuwahara, R., Kawaguchi S., Kohara Y., Jojima T., Yamashita K.

  Systemic or intra-hippocampal bisphenol A on exploratory activity, passive avoidance and spatial learning in rats
  Kuwahara, R., Kawaguchi S., Kohara Y., Jojima T., Yamashita K. - 2014

  EXPLORATORY ACTIVITY   AVOIDANCE   SPATIAL ORIENTATION AND SPATIAL MEMORY   GONADAL HORMONES   STEROTYPED BEHAVIORS   HIPPOCAMPUS, FORNIX AND SUBICULUM
Contained in: Learn. Mem., 2014: 21, 119-126

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

Authors: Kobilo, T., Guerrieri D., Zhang Y., Collica S.C., Becker K.G., van Praag H.

  AMP kinase on locomotion/exploration and spatial learning in young and aged mice
  Kobilo, T., Guerrieri D., Zhang Y., Collica S.C., Becker K.G., van Praag H. - 2014

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   AGE
Contained in: Pharmacol. Biochem. Behav., 2014: 120, 88-94

Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice

Authors: Jung, I.H., Lee H.E., Park S.J., Ahn Y.J., Kwon G., Woo H., Lee S.Y., Kim J.S., Jo Y.-W., Jang D.S., Kang S.S., Ryu J.H.

  Spinosin flavonoid on hippocampal extracellular signal-regulated kinase/CREB, exploratory activity and memory impairment by scopolamine in mice: 5-HT1A agonists modulation
  Jung, I.H., Lee H.E., Park S.J., Ahn Y.J., Kwon G., Woo H., Lee S.Y., Kim J.S., Jo Y.-W., Jang D.S., Kang S.S., Ryu J.H. - 2014

  EXPLORATORY ACTIVITY   AVOIDANCE   ACETYLCHOLINE   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS   SEROTONIN   PROTEINS AND GENES
Contained in: Physiol. Behav., 2014: 129, 118-129

Increase of glucocorticoid receptor expression after environmental enrichment: relations to spatial memory, exploration and anxiety-related behaviors

Authors: Sampedro-Piquero, P., Begega A., Arias J.L.

  Environmental enrichment on hippocampal glucocorticoid receptor expression, exploratory activity and spatial learning in rats
  Sampedro-Piquero, P., Begega A., Arias J.L. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   ENVIRONMENT AND SOCIAL BEHAVIOR   GLUCOCORTICOIDS   HIPPOCAMPUS, FORNIX AND SUBICULUM
Contained in: Nature, 2014: 508, 88-92

The hippocampal CA2 region is essential for social memory

Authors: Hitti, F.L., Siegelbaum S.A.

  Hippocampal CA2 region on exploratory activity, social learning, Morris water maze performance, fear conditioning and olfactory memory in mice
  Hitti, F.L., Siegelbaum S.A. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   ENVIRONMENT AND SOCIAL BEHAVIOR   FEAR AND RELATED BEHAVIORS   HIPPOCAMPUS, FORNIX AND SUBICULUM   SMELL
Contained in: Learn. Mem., 2014: 21, 205-214

Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum

Authors: Simpson, E.H., Morud J., Winiger V., Biezonski D., Zhu J.P., Bach M.E., Malleret G., Polan H.J., Ng-Evans S., Phillips P.E.M., Kellendonk C., Kandel E.R.

  Catechol-O-methyl transferase activity on locomotion/exploration, spatial learning and prepulse inhibition od startle reflex in mice: dopamine striatal release
  Simpson, E.H., Morud J., Winiger V., Biezonski D., Zhu J.P., Bach M.E., Malleret G., Polan H.J., Ng-Evans S., Phillips P.E.M., Kellendonk C., Kandel E.R. - 2014

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   CEREBELLUM   SPATIAL ORIENTATION AND SPATIAL MEMORY   OPERANT CONDITIONING   CEREBRAL CORTEX   DOPAMINE   CONDITIONED AND UNCONDITIONED INHIBITION   HIPPOCAMPUS, FORNIX AND SUBICULUM   STARTLE REFLEX   STRIATUM
Contained in: Physiol. Behav., 2014: 130, 40-46

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning, and memory but impairs passive avoidance learning and memory, in offspring

Authors: Kohara, Y., Kuwahara R., Kawaguchi S., Jojima T., Yamashita K.

  Perinatal exposure to phytoestrogen genistein on exploratory activity, spatial learning and passive avoidance in male and female rat offspring
  Kohara, Y., Kuwahara R., Kawaguchi S., Jojima T., Yamashita K. - 2014

  EXPLORATORY ACTIVITY   AVOIDANCE   SPATIAL ORIENTATION AND SPATIAL MEMORY   GENDER   GONADAL HORMONES
Contained in: Physiol. Behav., 2014: 130, 176-181

Measuring attention in a Parkinson's disease rat model using the 5-arm maze test

Authors: Ho, S.-C., Hsu C.-C., Yu C.-H., Huang W.-N., Tikhonova M.A., Ho M.-C., Hung C.-S., Amstislavskaya T.G., Ho Y.-J.

  Dopaminergic nigra neuron lesions on exploratory activity and spatial learning in rats
  Ho, S.-C., Hsu C.-C., Yu C.-H., Huang W.-N., Tikhonova M.A., Ho M.-C., Hung C.-S., Amstislavskaya T.G., Ho Y.-J. - 2014

  EXPLORATORY ACTIVITY   CENTRAL NERVOUS SYSTEM LESIONS   SPATIAL ORIENTATION AND SPATIAL MEMORY   DOPAMINE   SUBSTANTIA NIGRA
Contained in: Nat. Neurosci., 2014: 17, 971-980

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Authors: Hait, N.C., Wise L.E., Allegood J.C., O’Brien M., Avni D., Reeves T.M., Knapp P.E., Lu J., Luo C., Miles M.F., Milstien S., Lichtman A.H., Spiegel S.

  Fingolimod on hippocampal long-term potentiation, exploratory activity, Morris water maze performance, fear condeitioning acquisition and extinction via histone deacetylase inhibition in mice
  Hait, N.C., Wise L.E., Allegood J.C., O’Brien M., Avni D., Reeves T.M., Knapp P.E., Lu J., Luo C., Miles M.F., Milstien S., Lichtman A.H., Spiegel S. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   EXTINCTION   FEAR AND RELATED BEHAVIORS   PROTEINS AND GENES
Contained in: J. Neurosci., 2014: 34, 804-816

Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory

Authors: Terunuma, M., Revilla-Sanchez R., Quadros I.M., Deng Q., Deeb T.Z., Lumb M., Sicinski P., Haydon P.G., Pangalos M.N., Moss S.J.

  GABA-B receptor role in hippocampal neuron excitability and plasticity, fear conditioning, spatial learning and exploratory activity in mice
  Terunuma, M., Revilla-Sanchez R., Quadros I.M., Deng Q., Deeb T.Z., Lumb M., Sicinski P., Haydon P.G., Pangalos M.N., Moss S.J. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   FEAR AND RELATED BEHAVIORS   γ-AMINO-BUTYRIC ACID (GABA)   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   PROTEINS AND GENES
Contained in: J. Neurosci., 2014: 34, 1067-1080

Encoding of head direction by hippocampal place cells in bats

Authors: Rubin, A., Yartsev M.M., Ulanovsky N.

  Hippocampal place cells and head direction in bats
  Rubin, A., Yartsev M.M., Ulanovsky N. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM
Contained in: Psychopharmacology, 2014: 231, 2941-2954

Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior

Authors: Hansen III, R.T., Conti M., Zhang H.-T.

  Phosphodiesterase-4A on exploration, neophobia, learning and response to stress in mice
  Hansen III, R.T., Conti M., Zhang H.-T. - 2014

  EXPLORATORY ACTIVITY   AVOIDANCE   SPATIAL ORIENTATION AND SPATIAL MEMORY   DARK/LIGHT CONTEXT   NEOPHOBIA   STRESS
Contained in: Behav. Brain Res., 2014: 271, 59-64

Enriched environment improves the cognitive effects from traumatic brain injury in mice

Authors: Schreiber, S., Lin R., Haim L., Baratz-Goldstein R., Rubovitch V., Vaisman N., Pick C.G.

  Environmental enrichment on learning and exploration impairment by traumatic brain injury in mice
  Schreiber, S., Lin R., Haim L., Baratz-Goldstein R., Rubovitch V., Vaisman N., Pick C.G. - 2014

  EXPLORATORY ACTIVITY   CENTRAL NERVOUS SYSTEM LESIONS   SPATIAL ORIENTATION AND SPATIAL MEMORY   ENVIRONMENT AND SOCIAL BEHAVIOR
Contained in: Behav. Brain Res., 2014: 271, 116-121

Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress

Authors: Liu, D., Wang Z., Gao Z., Xie K., Zhang Q., Jiang H., Pang Q.

  Curcumin on stress effects on Morris water maze performance, locomotion, exploration, neophobia and hippocampal brain derived neurotrophic factor, extracellular signal-regulated kinase expression in rats
  Liu, D., Wang Z., Gao Z., Xie K., Zhang Q., Jiang H., Pang Q. - 2014

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   NEOPHOBIA   NEUROTROPHIC FACTORS   PROTEIN KINASES   STRESS
Contained in: Science, 2014: 345, 814-817

Large environments reveal the statistical structure governing hippocampal representations

Authors: Rich, P.D., Liaw H.-P., Lee A.K.

  Environmental exploration and spatial representation in hippocampal place cells of rats
  Rich, P.D., Liaw H.-P., Lee A.K. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM
Contained in: Hippocampus, 2014: 24, 1006-1016

Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging

Authors: Castellano, J.F., Fletcher B.R., Patzke H., Long J.M., Sewal A., Kim D.H., Kelley-Bell B., Rapp P.R.

  Histone deacetylase inhibitor on hippocampal histone acetylation, exploratory activity, fear conditioning and Morris water maze performance in rats and mice of different age
  Castellano, J.F., Fletcher B.R., Patzke H., Long J.M., Sewal A., Kim D.H., Kelley-Bell B., Rapp P.R. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   AGE   FEAR AND RELATED BEHAVIORS   HIPPOCAMPUS, FORNIX AND SUBICULUM   PROTEINS AND GENES
Contained in: Plos, Biol., 2014: 12, e1001923 (1-17)

Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease

Authors: Xu, J., Chatterjee M.X., Baguley T.D., Brouillette J., Kurup P., Ghosh D., Kanyo J., Zhang Y., Seyb K., Ononenyi C., Foscue E., Anderson G.M., Gresack J., Cuny G.D., Glicksman M.A., Greengard P., Lam T.T., Tautz L., Nairn A.C., Eilman J.A., Lombroso P.J.

  Tyrosine phosphatase STEP inhibitor on exploration and memory in mice
  Xu, J., Chatterjee M.X., Baguley T.D., Brouillette J., Kurup P., Ghosh D., Kanyo J., Zhang Y., Seyb K., Ononenyi C., Foscue E., Anderson G.M., Gresack J., Cuny G.D., Glicksman M.A., Greengard P., Lam T.T., Tautz L., Nairn A.C., Eilman J.A., Lombroso P.J. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   GLUTAMATE   N-METHYL-D-ASPARTATE (NMDA)   PROTEIN KINASES
Contained in: Neuroscience, 2014: 275, 238-247

Loss of glutamic acid decarboxylase (GAD67) in GPR88¬-expressing neurons induces learning and social behavior deficits in mice

Authors: Zhang, K., Hill K., Labak S., Blatt G.J., Soghomonian J.-J.

  Glutamic acid decarboxylase deficit on social behavior, locomotion, exploration and spatial learning in mice
  Zhang, K., Hill K., Labak S., Blatt G.J., Soghomonian J.-J. - 2014

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   ENVIRONMENT AND SOCIAL BEHAVIOR   γ-AMINO-BUTYRIC ACID (GABA)
Contained in: Neuroscience, 2014: 277, 506-521

Genetic deletion of MT1/MT2 melatonin receptors enhances murine cognitive and motor performance

Authors: O'Neal-Moffitt, G., Pilli J., Kumar S.S., Olcese J.

  MT1 and MT2 melatonin receptors on locomotion, exploration, circadian activity, hippocampal long-term potentiation, spatial learning and hippocampal and cortical plasticity in mice of different age
  O'Neal-Moffitt, G., Pilli J., Kumar S.S., Olcese J. - 2014

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   AGE   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   MELATONIN   NEUROGENESIS AND PLASTICITY   CIRCADIAN RHYTHMS
Contained in: Pharmacol. Biochem. Behav., 2014: 124, 58-66

WIN55,212-2 impairs non-associative recognition and spatial memory in rats via CB1 receptor stimulation

Authors: Galanopoulos, A., Polissidis A., Georgiadou G., Papadopoulou-Daifoti Z., Nomikos G.G., Pitsikas N., Antoniou K.

  CB1 agonists on locomotion, exploration, spatial learning and object recognition in rats
  Galanopoulos, A., Polissidis A., Georgiadou G., Papadopoulou-Daifoti Z., Nomikos G.G., Pitsikas N., Antoniou K. - 2014

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   CANNABINOIDS   SPATIAL ORIENTATION AND SPATIAL MEMORY
Contained in: Pharmacol. Biochem. Behav., 2014: 124, 373-379

Pretreatment with antiasthmatic drug ibudilast ameliorates Aβ1-42-induced memory impairment and neurotoxicity in mice

Authors: Wang, H., Mei Z.I., Zhong K.L., Hu M., Long Y., Miao M.X., Li N., Yan T.H., Hong H.

  Ibudilast on amyloid-β1-42-induced neurotoxicity and exploration and memory impairment in mice
  Wang, H., Mei Z.I., Zhong K.L., Hu M., Long Y., Miao M.X., Li N., Yan T.H., Hong H. - 2014

  EXPLORATORY ACTIVITY   CENTRAL NERVOUS SYSTEM LESIONS   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   HIPPOCAMPUS, FORNIX AND SUBICULUM
Contained in: Neurobiol. Learn. Mem., 2014: 114, 32-39

cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits

Authors: Wincott, C.M., Abera S., Vunck S.A.,Tirko N.,Choi Y., Titcombe R.F., Antoine S.O., Tukey D.S., DeVito L.M., Hofmann F., Hoeffer C.A., Ziff E.B.

  cGMP-dependent protein kinase type II on neophobia, spatial learning, exploratory activity and social behavior in mice: glutamate receptor modulation
  Wincott, C.M., Abera S., Vunck S.A.,Tirko N.,Choi Y., Titcombe R.F., Antoine S.O., Tukey D.S., DeVito L.M., Hofmann F., Hoeffer C.A., Ziff E.B. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   ENVIRONMENT AND SOCIAL BEHAVIOR   GLUTAMATE   NEOPHOBIA   N-METHYL-D-ASPARTATE (NMDA)   PROTEIN KINASES
Contained in: Brain Res., 2014: 1577, 77-88

Irradiation-induced hippocampal neurogenesis impairment is associated with epigenetic regulation of bdnf gene transcription

Authors: Ji, S., Tian Y., Lu Y., Sun R., Ji J., Zhang L., Duan S.

  Brain irradiation on exploratory activity, passive avoidance, Morris water maze performance, hippocampal neurogenesis, epigenetic regulation and brain derived neurotrophic factor expression in rats
  Ji, S., Tian Y., Lu Y., Sun R., Ji J., Zhang L., Duan S. - 2014

  EXPLORATORY ACTIVITY   AVOIDANCE   CENTRAL NERVOUS SYSTEM LESIONS   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   NEUROTROPHIC FACTORS   NEUROGENESIS AND PLASTICITY   PROTEINS AND GENES
Contained in: Hippocampus, 2014: 24, 1059-1069

Impaired hippocampus-dependent spatial flexibility and sociability represent autism-like phenotypes in GluK2 mice

Authors: Micheau, J., Vimeney A., Normand E., Mulle C., Riedel G.

  GluK2 receptor role in exploratory activity, social behavior and spatial learning in mice
  Micheau, J., Vimeney A., Normand E., Mulle C., Riedel G. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   ENVIRONMENT AND SOCIAL BEHAVIOR
Contained in: Hippocampus, 2014: 24, 1197-1211

Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling

Authors: Hill, R.A., Klig M., Von Soly S.K., Binder M.D., Hannan A.J., van den Buuse M.

  Corticosterone on hippocampal brain derived neurotrofic factor expression, exploratory activity and anhedonia in male and female rats
  Hill, R.A., Klig M., Von Soly S.K., Binder M.D., Hannan A.J., van den Buuse M. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   GENDER   GLUCOCORTICOIDS   HIPPOCAMPUS, FORNIX AND SUBICULUM   NEUROTROPHIC FACTORS
Contained in: J. Neurosci., 2014: 34, 3056-3066

The hippocampal CA2 ensemble is sensitive to contextual change

Authors: Wintzer, M., Boehringer R., Polygalov D., McHugh T.J.

  Hippocampal CA2 neuron and contextual learning in mice: NMDA-induced seizure study
  Wintzer, M., Boehringer R., Polygalov D., McHugh T.J. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   N-METHYL-D-ASPARTATE (NMDA)   NEUROGENESIS AND PLASTICITY
Contained in: J. Neurosci., 2014: 34, 3033-3041

A map of LTP-related synaptic changes in dorsal hippocampus following unsupervised learning

Authors: Cox, C.D., Rex C.S., Palmer L.C., Babayan A.H., Pham D.T., Corwin S.D., Trieu B.H., Gall C.M., Lynch G.

  Exploration and spatial orientation on hippocampal long-term potentiation and calcium calmodulin kinase II expression in rats
  Cox, C.D., Rex C.S., Palmer L.C., Babayan A.H., Pham D.T., Corwin S.D., Trieu B.H., Gall C.M., Lynch G. - 2014

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   PROTEIN KINASES