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2015
Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey
Authors: Vardigan, J.D., Cannon C.E. Puri V., Dancho M., Koser A.J., Wittmann M., Kuduk S.D., Renger J.J., Uslaner J.M. M1 muscarinic potentiator, donezipil or xanomeline on scopolamine-induced operant conditioning impairment in monkeys
Vardigan, J.D., Cannon C.E. Puri V., Dancho M., Koser A.J., Wittmann M., Kuduk S.D., Renger J.J., Uslaner J.M. - 2015
DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice
Authors: Yang, R.-Y., Zhao G., Wang D.-M., Pang X.-C., Wang S.-B., Fang J.-S., Li C., Liu A.-L., Wu S., Du G.-H. Cholinesterase inhibitor DL0410, rivastigmine and memantine on Morris water maze performance, passive avoidance, object recognition, hippocampal plasticity and NMDAR/calcium calmodulin kinase II/PSD-95 expression in APP/PS1 and control mice
Yang, R.-Y., Zhao G., Wang D.-M., Pang X.-C., Wang S.-B., Fang J.-S., Li C., Liu A.-L., Wu S., Du G.-H. - 2015
Reversal effects of crocin on amyloid β-induced memory deficit: modification of autophagy or apoptosis markers
Authors: Asadi, F., Jamshidi A.H., Khodagholi F., Yans A., Azimi L., Faizi M., Vali L., Abdollahi M., Ghahremani M.H., Sharifzadeh M. Systemic or intra-hippocampal carotenoid crocin on Morris water maze impairment by intra-hippocampal amyloid-β 1-42 injected in rats
Asadi, F., Jamshidi A.H., Khodagholi F., Yans A., Azimi L., Faizi M., Vali L., Abdollahi M., Ghahremani M.H., Sharifzadeh M. - 2015
Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats
Authors: Abdel-Wahab, B.A., Shaikh I.A., Khateeb M.M., Habeeb S.M. Omega-3 and levetiracetam on hippocampal oxidative stress, exploratory and congitive impairment by kindling in rats
Abdel-Wahab, B.A., Shaikh I.A., Khateeb M.M., Habeeb S.M. - 2015
Free and Easy Wanderer Plus (FEWP) improves behavioral deficits in an animal model of post-traumatic stress disorder by stimulating allopregnanolone biosynthesis
Authors: Qiu, Z.-K., Zhang G.-H., He J.-L., Ma J.-C., Zeng J., Shen D., Shen Y.-G., Chen J.-S., Liu C.-Y. "Free and easy wanderer plus" chinese medicine on locomotion/exploration and fear conditioning impairment induced by stress in male rats: brain allopregnenolone levels study
Qiu, Z.-K., Zhang G.-H., He J.-L., Ma J.-C., Zeng J., Shen D., Shen Y.-G., Chen J.-S., Liu C.-Y. - 2015
Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats
Authors: Tian, Y., Guo S., Wu X., Ma L., Zhao X. Minocycline on sevofluraneanesthesia-induced Morris water maze performance impairment and hippocampal amyloid β deposition in aged rats
Tian, Y., Guo S., Wu X., Ma L., Zhao X. - 2015
Preliminary evidence that abscisic acid improves spatial memory in rats
Authors: Qi, C.-C., Ge J.-F., Zhou J.-N. Abscisic acid on spatial learning and exploratory activity in rats
Qi, C.-C., Ge J.-F., Zhou J.-N. - 2015
Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation
Authors: Kohara, Y., Kawaguchi S., Kuwahara R., Uchida Y., Oku Y., Yamashita K. Phytoestrogen genistein and glucose on spatial learning, passive avoidance and exploratory activity in rats
Kohara, Y., Kawaguchi S., Kuwahara R., Uchida Y., Oku Y., Yamashita K. - 2015
Type 4 phopshodiesterase enzyme inhibitor, rolipram rescues behavioral deficits in olfactory bulbectomy models of depression: involvement of hypothalamic-pituitary-adrenal axis, cAMP signaling aspects and antioxidant defense system
Authors: Jindal, A., Mahesh R., Bhatt S. Rolipram on olfactory bulbectomy effects on exploratory activity, neophobia, response to stress and oxidative stress response in rats: antidepressant effects extimation
Jindal, A., Mahesh R., Bhatt S. - 2015
The effects of Ginkgo biloba extract on cognitive functions in aged female rats: the role of oxidative stress and brain-derived neurotrophic factor
Authors: Belviranli, M., Okudan N. Ginkgo biloba extract on exploratory activity and Morris water maze perfomance in female rats of different age
Belviranli, M., Okudan N. - 2015
Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain
Authors: Souza, L.C., Antunes M.S., Filho C.B., Del Fabbro L., de Gomes M.G., Rossito Goes A.T., Donato F., Prigol M., Boeira S.P., Jesse C.R. Flavonoid Chrysin on oxidative stress, brain derived neurotrophic factor levels, exploratory activity and Morris water maze performance in adult and aged mice
Souza, L.C., Antunes M.S., Filho C.B., Del Fabbro L., de Gomes M.G., Rossito Goes A.T., Donato F., Prigol M., Boeira S.P., Jesse C.R. - 2015
Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice
Authors: Lee, Y., Gao Q., Kim E., Lee Y., Park S.J., Lee H.E., Jang D.S., Ryu J.H. 5-hydroxymethyl-2-furaldeyde on exploratory activity, passive avoidance and spatial memory impairment by scopolamine in mice: NMDA, calcium calmodulin kinase II and extracellular signal-regulated kinase modulation
Lee, Y., Gao Q., Kim E., Lee Y., Park S.J., Lee H.E., Jang D.S., Ryu J.H. - 2015
Lacosamide reduces HDAC levels in the brain and improves memory: potential for treatment of Alzheimer's disease
Authors: Bang, S.R., Ambavade S.D., Jagdale P.G., Adkar P.P., Waghmare A.B., Ambavade P.D. Histone deacetylase inhibitor locosomide on cortical acetylcholinesterase levels, exploratory activity, object recognition and spatial learning in scopolamine treated mice and rats
Bang, S.R., Ambavade S.D., Jagdale P.G., Adkar P.P., Waghmare A.B., Ambavade P.D. - 2015
Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits
Authors: Jiao, S.-S., Yao X.-Q., Liu Y.-H., Wang Q.-H., Zeng F., Lu J.-J., Liu J., Zhu C., Shen L.-L., Liu C.-H., Wang Y.-R., Zeng G.-H., parikh A., Chen J., Liang C.-R., Xiang Y., Bu X.-L., Deng J., Li J., Xu J., Zeng Y.-Q., Xu X., Xu H.-W., Zhong J.-H., Zhou H.-D., Zhou X.-F., Wang Y.-J. Free radical scavenger Edaravone on Aβ deposition, oxidative stress, exploratory activity and Morris water maze performance impairment in APP mice
Jiao, S.-S., Yao X.-Q., Liu Y.-H., Wang Q.-H., Zeng F., Lu J.-J., Liu J., Zhu C., Shen L.-L., Liu C.-H., Wang Y.-R., Zeng G.-H., parikh A., Chen J., Liang C.-R., Xiang Y., Bu X.-L., Deng J., Li J., Xu J., Zeng Y.-Q., Xu X., Xu H.-W., Zhong J.-H., Zhou H.-D., Zhou X.-F., Wang Y.-J. - 2015
Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)
Authors: Nakajima, A., Aoyama Y., Shin E.-J., Nam Y., Kim H.-C., Nagai T., Yokosuka A., Mimaki Y., Yokoi T., Ohizumi Y., Yamada K. Nobiletin on soluble amyloid β level, oxidative stress, locomotion/exploration, passive avoidance, object recognition and spatial learning in 3xTg-AD and control mice
Nakajima, A., Aoyama Y., Shin E.-J., Nam Y., Kim H.-C., Nagai T., Yokosuka A., Mimaki Y., Yokoi T., Ohizumi Y., Yamada K. - 2015
Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipram
Authors: Callaghan, C.K., O'Mara S.M. Rolipram on chemotherapic docetaxel effects on exploratory activity, response to stress and object recognition in rats
Callaghan, C.K., O'Mara S.M. - 2015
Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances
Authors: Quiedeville, A., Boulouard M., Hamidouche K., Da Silva Costa-Aze V., Nee G., Rochais C., Dallemagne P., Fabis F., Freret T., Bouet V. 5-HT4 and 5-HT6 modulation in locomotion/exploration on object recognition of mice
Quiedeville, A., Boulouard M., Hamidouche K., Da Silva Costa-Aze V., Nee G., Rochais C., Dallemagne P., Fabis F., Freret T., Bouet V. - 2015
Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice
Authors: McClean, P.L., Jalewa J., Holscher C. Antidiabetic liraglutide on exploratory activity, spatial learning, object recognition and hippocampal long-term potentiation in control and APP/PS1 mice
McClean, P.L., Jalewa J., Holscher C. - 2015
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
Authors: Sabogal-Guaqueta, A.M., Munoz-Manco J.I., Ramirez-Pineda J.R., Lamprea-Rodriguez M., Osorio E., Cardona-Gomez G.P. Flavonoid quercetin on exploratory activity, Morris water maze performance and neuroprotection in 3xTg-AD and control mice
Sabogal-Guaqueta, A.M., Munoz-Manco J.I., Ramirez-Pineda J.R., Lamprea-Rodriguez M., Osorio E., Cardona-Gomez G.P. - 2015
Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus
Authors: Robitsek, J., Ratner M.H., Stewart T., Eichenbaum H., Farb D.H. Levetiracetam and valpoic acid on exploration-dependent hippocampal place cell firing in rats of different age
Robitsek, J., Ratner M.H., Stewart T., Eichenbaum H., Farb D.H. - 2015
Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice
Authors: Jiang, J.H., He Z., Peng Y.L., Jin W.D., Wang Z., Mu L.Y., Chang M., Wang R. Intracerebroventricular neuropeptide phoenixin-14 on systemic scopolamine or intracerebroventricular amyloid β1-42 effects on locomotion/exploration/grooming and object location/recognition in mice
Jiang, J.H., He Z., Peng Y.L., Jin W.D., Wang Z., Mu L.Y., Chang M., Wang R. - 2015
Inhibition of glycogen synthase kinase-3β enhances cognitive r3ecxovery after stroke: the role of TAK1
Authors: Venna, V.R., Benashski S.E., Chauhan A., McCullough L.D. Glycogen synthase kinase-3β inhibitor on post-stroke cognitive, locomotion, exploration recovery in mice: TAKI role
Venna, V.R., Benashski S.E., Chauhan A., McCullough L.D. - 2015
Resveratrol exerts anti-inflammatory and neuroprotective effects to prevent memory deficits in rats exposed to chronic unpredictable mild stress
Authors: Yazir, Y., Utkan T., Gacar N., Aricioglu F. Resveratrol on stress-dependent memory and hippocampal brain derived neurotrophic factor and c-fos protein expression deficit in rats
Yazir, Y., Utkan T., Gacar N., Aricioglu F. - 2015
Modafinil as a cognitive enhancer of spatial working memory in rats
Authors: Murphy, H.M., Ekstrand D., Tarchick M., Wideman C.H. Modafinil on feeding, locomotion and Morris water maze performance in rats
Murphy, H.M., Ekstrand D., Tarchick M., Wideman C.H. - 2015
Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice
Authors: Budzynska, B., Boguszewska-Czubara A., Kruk-Slomska M., Skalicka-Wozniak K., Michalak A., Musik I., Biala G. Fouranocoumarin imperatonin on cortical, hippocampal oxidative stress, locomotor activity and passive avoidance in mice
Budzynska, B., Boguszewska-Czubara A., Kruk-Slomska M., Skalicka-Wozniak K., Michalak A., Musik I., Biala G. - 2015
Protective effect of exercise and sildenafil on acute stress and cognitive function
Authors: Ozbeyli, D., Gokalp A.G., Koral T., Ocal O.Y., Dogan B., Akakin D., Yuksel M., Kasimay O. Exercise and sildenofil on exploratory activity, object recognition, oxidative stress and response to stress in rats
Ozbeyli, D., Gokalp A.G., Koral T., Ocal O.Y., Dogan B., Akakin D., Yuksel M., Kasimay O. - 2015
Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments
Authors: Shi, S., Zhao X., Liu A., Liu B., Li H., Wu B., Bi K., Jia Y. Alpinia oxyphylla extract on neuroprotection and learning deficit by intra-cerebroventricular β amyloid 1-42 in mice
Shi, S., Zhao X., Liu A., Liu B., Li H., Wu B., Bi K., Jia Y. - 2015
The treatment combination of vitamins E and C and astaxanthin prevents high-fat diet induced memory deficits in rats
Authors: Komaki, A., Karimi S.A., Salehi I., Sarihi A., Shahidi S., Zarei M. Astoxantin, vitamins E and C on high-fat diet-induced passive avoidance impairment in rats
Komaki, A., Karimi S.A., Salehi I., Sarihi A., Shahidi S., Zarei M. - 2015
Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats
Authors: Hasanein, P., Mahtaj A.K. Rosmarinic acid and donepezil on scopolamine passive avoidance impairment in rats
Hasanein, P., Mahtaj A.K. - 2015
Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57BL/6 mice
Authors: Jiang, Y., Liu Y., Zhu C., Ma X., Ma L., Zhou L., Huang Q., Cen L., Pi R., Chen X. Minocycline on hippocamal plasticity, excitability, Morris water maze performance in mice of different age
Jiang, Y., Liu Y., Zhu C., Ma X., Ma L., Zhou L., Huang Q., Cen L., Pi R., Chen X. - 2015