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2016
Cognitive benefits of memantine in Alzheimer's 5XFAD model mice decline during advanced disease stages
Authors: Devi, L., Ohno M. Memantine on fear conditioning, spatial learning and cerebral Aβ42 oligomer levels in 5XFAD and control mice of different age
Devi, L., Ohno M. - 2016
The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease
Authors: Gu, X.-H., Xu L.-J., Liu Z.-Q., Wei B., Yang Y.-J., Xu G.-G., Yin X.-P., Wang W. Flavonoid baicalein on amyloid precursor protein-induced hippocampal neuron excitability, hippocampal and cortical plasticity, Morris water maze performance, fear conditioning and object recognition impairment in mice
Gu, X.-H., Xu L.-J., Liu Z.-Q., Wei B., Yang Y.-J., Xu G.-G., Yin X.-P., Wang W. - 2016
Chronic treatment with levetiracetam reverses deficits in hipocampal LTP in vivo in experimental temporal lobe epilesy rats
Authors: Ge, Y.-X., Tian X.-Z., Lin Y.-Y., Liu X.-Y. Leviracetam on hippocampal long-term potentiation and spatial learning in pilocarpine-induced status epilepticus rats
Ge, Y.-X., Tian X.-Z., Lin Y.-Y., Liu X.-Y. - 2016
Silibinin rescues learning and memory deficits by attenuating microglia activation and preventing neuroinflammatory reactions in SAMP8 mice
Authors: Jin, G., Bai D., Yin S., Yang Z., Zou D., Zhang Z., Li X., Sun Y., Zhu Q. Memantine and silibilinen hippocampal/cortical neuroinflammation, object recognition and Morris water maze impairment in SAMP8 mice
Jin, G., Bai D., Yin S., Yang Z., Zou D., Zhang Z., Li X., Sun Y., Zhu Q. - 2016
Tongluo Xingnao Effervescent Tablet preserves mitochondrial energy metabolism and attenuates cognition deficits in APPswe/PS1De9 mice
Authors: Dai, Y., Ma T., Ren X., Wei J., Fu W., Ma Y., Xu S., Zhang Z. Tongluo Xingnao Effervescent Tablet herbal extract on mitochrondial function and spatial learning in APP and control mice
Dai, Y., Ma T., Ren X., Wei J., Fu W., Ma Y., Xu S., Zhang Z. - 2016
Resveratrol limits diabets-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity
Authors: Tian, X., Liu Y., Ren G., Yin L., Liang X., Geng T., Dang H., An R. Resveratrol poliphenol on hippocampal neuron synaptic proteins, oxidative stress levels and spatial learning in streptozotocin-induced diabetes and control rats
Tian, X., Liu Y., Ren G., Yin L., Liang X., Geng T., Dang H., An R. - 2016
Effects of (-)-sesamin on motor and memory deficits in an MPTP-lesioned mouse model of Prkinson's disease treated with L-DOPA
Authors: Zhao, T.T., Shin K.S., Kim K.S., Park H.J., Kim H.J., Lee K.E., Lee M.K. Sesamin on nigro-striatal monoamine levels, hippocampal NMDA/ERK1-2/CREB expression, locomotion, exploration and passive avoidance performance in dopaminergic-lesioned mice
Zhao, T.T., Shin K.S., Kim K.S., Park H.J., Kim H.J., Lee K.E., Lee M.K. - 2016
Protective effects of salicylate on PKA inhibitor (H-89)-induced spatial memory deficit via lessening autophagy and apoptosis in rats
Authors: Azimi, L., Kachooeian M., Khodagholi F., Yans A., Haysieattalab S., Vakilzadeh G., Vosoughi N., Sanati M., Taghizadeh G., Sharifzadeh M. Intra-hippocampal or systemic acetylsalicilic acid and systemic donepezil on intra-hippocampal protein kinase A inhibitor effects on hippocampal apoptois, autophagy and spatial learning impairment in rats
Azimi, L., Kachooeian M., Khodagholi F., Yans A., Haysieattalab S., Vakilzadeh G., Vosoughi N., Sanati M., Taghizadeh G., Sharifzadeh M. - 2016
The effects of a 5-HT5A receptor antagonist in a ketamine-based rat model of cognitive dysfunction and the negative symptoms of schizophrenia
Authors: Nikiforuk, A., Holuj M., Kos T., Popik P. 5-HT5A antagonist on social interaction, object recognition and operant conditioning in ketamine-impaired and control rats
Nikiforuk, A., Holuj M., Kos T., Popik P. - 2016
Modulation of glycine sites enhances social memory in rats using PQQ combine with D-serine
Authors: Zhou, X., Liu D., Zhang R., Peng Y., Qin X., Mao S. Pyrroloquinoline quinone and D-serine on social interaction learning in rats
Zhou, X., Liu D., Zhang R., Peng Y., Qin X., Mao S. - 2016
Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach
Authors: Akkerman, S., Blokland A., Prickaerts J. Acetylcholinesterase and phosphodiesterase inhibitors on object recognition acquisition and consolidation in rats
Akkerman, S., Blokland A., Prickaerts J. - 2016
Effects of standardized Ginkgo biloba extract on the acquisition, retrieval and extinction of conditioned suppression: evidence that short-term memory and long-term memory are differentially modulated
Authors: Zamberlam, C.R., Vendrasco N.C., Oliveira D.R., Gaiardo R.B., Cerutti S.M. Ginkgo biloba extract on conditioned suppression acquisition, retrieval and extinction in rats
Zamberlam, C.R., Vendrasco N.C., Oliveira D.R., Gaiardo R.B., Cerutti S.M. - 2016
Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice
Authors: Hayama, T., Murakami K., Watanabe T., Maeda R., Kamata M., Kondo S. γ-secretase modulation on hippocampal neuron excitability, c-fos expression and novel object recognition performance in mice of different age
Hayama, T., Murakami K., Watanabe T., Maeda R., Kamata M., Kondo S. - 2016
Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet
Authors: Asadbegi, M., Yaghmaei P., Salehi I., Ebrahim-Habibi A., Komaki A. Metformin on high-fat diet or intra-hippocampal amyloid β injection induced hippocampal neuron excitability in rats
Asadbegi, M., Yaghmaei P., Salehi I., Ebrahim-Habibi A., Komaki A. - 2016
Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients
Authors: Nakagawa, T., Itoh M., Ohta K., Hayashi Y., Hayakawa M., Yamada Y., Akanabe H., Chikaishi T., Nakagawa K., Itoh Y., Muro T., Yanagida D., Nakabayashi R., Mori T., Saito K., Ohzawa K., Suzuki C., Li S., Ueda M., Wang M.-X., Nishida E., Islam S., Tana, Kobori M., Inizuka T. Flavonoid quercetin on fear conditioning in mice and cognitive performance in early-stage Alzheimer's disease human patients
Nakagawa, T., Itoh M., Ohta K., Hayashi Y., Hayakawa M., Yamada Y., Akanabe H., Chikaishi T., Nakagawa K., Itoh Y., Muro T., Yanagida D., Nakabayashi R., Mori T., Saito K., Ohzawa K., Suzuki C., Li S., Ueda M., Wang M.-X., Nishida E., Islam S., Tana, Kobori M., Inizuka T. - 2016
Acetyl-L-Carnitine restores synaptic transmission and enhances the inducicbility of stable LTP after oxygen-glucose deprivation
Authors: Kocsis, K., Frank R., Szabò J., Knapp L., Kis Z., Farkas T., Vecsei L., Toldi J. Acetyl-L-carnitine on hippocampal neuron excitability impairment by oxygen-glucose deprivation in rats: phosphoinositide 3 kinase role
Kocsis, K., Frank R., Szabò J., Knapp L., Kis Z., Farkas T., Vecsei L., Toldi J. - 2016
Discrimination performance in aging is vulnerable to interference and dissociable from spatial memory
Authors: Johnson, S.A., Sacks P.K., Turner S.M., Gaynor L.S., Ormerod B.K., Maurer A.P., Bizon J.L., Burke S.N. Donepezil effects on spatial navigation/discrimination in young and aged rats
Johnson, S.A., Sacks P.K., Turner S.M., Gaynor L.S., Ormerod B.K., Maurer A.P., Bizon J.L., Burke S.N. - 2016
The effects of ginsenoside Rg1 on cronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats
Authors: Liu, Z., Qi Y., Cheng Z., Zhu X., Fan C., Yu S.Y. Ginsenoside Rg1 on chronic stress effects on sucrose preference, response to stress, lateral amygdalar plasticity and brain-derived neurotrophic factor/protein kinase A/CREB expression in young rats
Liu, Z., Qi Y., Cheng Z., Zhu X., Fan C., Yu S.Y. - 2016
Stimulant drug effects on touchscreen automated paired-associates learning (PAL) in rats
Authors: Roschlau, C., Votteler A., Hauber W. Modafinil, methylphenidate, amphetamine and MK-801 on operant responding recall in rats
Roschlau, C., Votteler A., Hauber W. - 2016
2015
Investigation of the role of non-selective calcium channel blocker (flunarizine) on cerebral ischemic-reperfusion associated cognitive dysfunction in aged mice
Authors: Gulati, P., Muthuraman A., Kaur P. Calcium channel blocker flunarizine on locomotor and spatial learning impairment by ischemia in aged mice
Gulati, P., Muthuraman A., Kaur P. - 2015
Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models
Authors: Bali, Z.K., Inkeller J., Csurgyok R., Bruszt N., Horvath H., Hernadi I. α7 nicotinic agonist on MK-801- and scopolamine-induced amnesia of spatial learning in rats
Bali, Z.K., Inkeller J., Csurgyok R., Bruszt N., Horvath H., Hernadi I. - 2015
Preteatment with curcumin attenuates anxiety while strengthens memory performance after one short stress experience in male rats
Authors: Haider, S., Naqvi F., Batool Z., Tabassum S., Sadir S., Liaquat L., Naqvi F., Zuberi N.A., Shakeel H., Perveen T. Stress and curcumin on oxidative stress, brain acetylcholine, exploratory activity, response to stress and Morris water maze performance in rats
Haider, S., Naqvi F., Batool Z., Tabassum S., Sadir S., Liaquat L., Naqvi F., Zuberi N.A., Shakeel H., Perveen T. - 2015
Enhanced behavioral response by decreasing brain oxidative stress to 6-hydroxy-L-nicotine in Alzheimer's disease rat model
Authors: Hritcu, L., Stefan M., Brandsch R., Mihasan M. Nicotine metabolite 6-hydroxy-L-nicotine on brain oxidative stress and spatial memory impairment by scopolamine in rats
Hritcu, L., Stefan M., Brandsch R., Mihasan M. - 2015
Memory recuperative potential of rifampicin in aluminum chloride-induced dementia: role of pregnane X receptors
Authors: Kaur, P., Sodhi R.K. Rifampicin on aluminium-chloride-induced locomotor, mnemonic and acetylcholinesterase level deficits in rats
Kaur, P., Sodhi R.K. - 2015
Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation
Authors: Guo, H.B., Cheng Y.F., Wu J.G., Wang C.M., Wang H.T., Zhang C., Qiu Z.K., Xu J.P. Cholinesterase inhibitor donepezil on object recognition, Morris water maze performance, brain Aβ40-42 levels and hippocampal microglia activation in Aβ-APP mice
Guo, H.B., Cheng Y.F., Wu J.G., Wang C.M., Wang H.T., Zhang C., Qiu Z.K., Xu J.P. - 2015
Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice
Authors: Ghumatkar, P.J., Patil S.P., Jain P.D., Tambe R.M., Sathaye S. Phloretin and donezepil on spatial learning, exploratory activity, hippocampal acetylcholine/brain-derived neurotrophic factor and oxidative stress impairment by scopolamine in mice
Ghumatkar, P.J., Patil S.P., Jain P.D., Tambe R.M., Sathaye S. - 2015
Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans
Authors: Theunissen, E.L., Heckman P., de Sousa E.B., Perna F., Kuypers K.P.C., Sambeth A., Blokland A., Prickaerts J., Toennes S.W., Ramaeckers J.G. Rivastigmine and vardenafil on cannabis-induced verbal memory impairment in humans
Theunissen, E.L., Heckman P., de Sousa E.B., Perna F., Kuypers K.P.C., Sambeth A., Blokland A., Prickaerts J., Toennes S.W., Ramaeckers J.G. - 2015
AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: studies in cognitively poor middle-aged mice
Authors: Gimenez-Llort, L., Ratia M., Perez B., Camps P., Munoz-Torrero D., Badia A., Clos M.V. Anticholinesterasic AVCRI104P3 and huprine X on exploratory activity and Morris water maze performance in middle-aged mice
Gimenez-Llort, L., Ratia M., Perez B., Camps P., Munoz-Torrero D., Badia A., Clos M.V. - 2015
The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model
Authors: Puri, V., Wang X., Vardigan J.D., Kuduk S.D., Uslaner J.M. Muscarinic modulation of object recognition in Tg2576 and control mice of different age
Puri, V., Wang X., Vardigan J.D., Kuduk S.D., Uslaner J.M. - 2015
Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAP/PI3K pathways
Authors: Li, J., Ding X., Zhang R., Jiang W., Sun X., Xia Z., Wang X., Wu E., Zhang Y., Hu Y. Harpagoside on intra-hippocampal amyloid-β1-40 induced cognitive impairment in rats: effects on cortical/hippocampal choline acetyltransferase/brain-derived neurotrophic factor/extracellular signal-regulated kinase expression
Li, J., Ding X., Zhang R., Jiang W., Sun X., Xia Z., Wang X., Wu E., Zhang Y., Hu Y. - 2015