2017

Contained in: Brain Res., 2017: 1657, 193-201

Long-term effects of repeated maternal separation and ethanol intake on HPA axis responsiveness in adult rats

Authors: Odeon, M.M., Yamauchi L., Grosman M., Acosta G.B.

  Neonatal cold stress, early maternal separation and ethanol exposure on hippocampal gluco-mineral-corticoid levels, hypothalamic-pituitary-adrenal axis functioning and response to stress in young adult rats
  Odeon, M.M., Yamauchi L., Grosman M., Acosta G.B. - 2017

  ADRENO-CORTICO-TROPIC-HORMONE (ACTH)   PITUITARY-ADRENAL AXIS   ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   HYPOTHALAMUS   HIPPOCAMPUS, FORNIX AND SUBICULUM   STRESS
Contained in: Neurobiol. Learn. Mem., 2017: 138, 252-270

Postnatal development of neurotransmitter systems and their relevance to extinction of conditioned fear

Authors: Kim, J.H., Perry C.J., Ganella D.E., Madsen H.B.

  Brain neurotransmitter development and conditioned fear extinction - Review
  Kim, J.H., Perry C.J., Ganella D.E., Madsen H.B. - 2017

  ACETYLCHOLINE   EPINEPHRINE AND NOREPINEPHRINE   AMYGDALA   CANNABINOIDS   CEREBRAL CORTEX   CORTICO-RELEASING-FACTOR (CRF)   AGE   DOPAMINE   EXTINCTION   FEAR AND RELATED BEHAVIORS   γ-AMINO-BUTYRIC ACID (GABA)   GLUTAMATE   HIPPOCAMPUS, FORNIX AND SUBICULUM   OPIOIDS   N-METHYL-D-ASPARTATE (NMDA)   OXYTOCIN   REVIEWS AND COMMENTARIES   SEROTONIN
Contained in: Nat. Neurosci., 2017: 20, 385-388

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Authors: Ramot, A., Jiang Z., Tian J.-B., Nahum T., Kuperman Y., Justice N., Chen A.

  Hypothalamic paraventricular nucleus corticotropin-releasing factor on response to social stress and related exploratory activity in mice
  Ramot, A., Jiang Z., Tian J.-B., Nahum T., Kuperman Y., Justice N., Chen A. - 2017

  PITUITARY-ADRENAL AXIS   EXPLORATORY ACTIVITY   ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   HYPOTHALAMUS   STRESS
Contained in: Neuroscience, 2017: 345, 176-192

Effects of stress on behavioral flexibility in rodents

Authors: Hurtubise, J.L., Howland J.G.

  Stress and related neurotransmitter levels on cognitive flexibility in rodents - Review
  Hurtubise, J.L., Howland J.G. - 2017

  EPINEPHRINE AND NOREPINEPHRINE   CEREBRAL CORTEX   CORTICO-RELEASING-FACTOR (CRF)   DOPAMINE   GLUCOCORTICOIDS   N-METHYL-D-ASPARTATE (NMDA)   REVIEWS AND COMMENTARIES   SEROTONIN   STRESS
Contained in: Neurosci. Biobehav. Rev., 2017: 74, 21-43

Neurobiological consequences of juvenile stress: a GABAergic perspective on risk and resilience

Authors: Albrecht, A. Muller I., Ardi Z., Caliskan G., Gruber D., Ivens S., Segal M., Behr J., Heinemann U., Stork O., Richter-Levin G.

  Juvenile stress, neurobiological alterations and GABAergic system - Review
  Albrecht, A. Muller I., Ardi Z., Caliskan G., Gruber D., Ivens S., Segal M., Behr J., Heinemann U., Stork O., Richter-Levin G. - 2017

  PITUITARY-ADRENAL AXIS   CORTICO-RELEASING-FACTOR (CRF)   γ-AMINO-BUTYRIC ACID (GABA)   GLUCOCORTICOIDS   HYPOTHALAMUS   HIPPOCAMPUS, FORNIX AND SUBICULUM   REVIEWS AND COMMENTARIES   STRESS
Contained in: Eur. J. Neurosci., 2017: 45, 797-804

Transient and persistent behavioral and molecular changes in primiparous female Wistar rats

Authors: Naik, R.R., de Jong T.R.

  Maternal experience on bedu nucleus of the stria terminalis/hypothalamic oxytocin/vasopressin/corticotropin-releasing hormone expression in female rats
  Naik, R.R., de Jong T.R. - 2017

  ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   GONADAL HORMONES   HYPOTHALAMUS   OXYTOCIN   VASOPRESSIN, VASOTOCIN
Contained in: Behav. Brain Res., 2017: 324, 146-154

The effects of CRF an urocortins in the preference for social novelty of mice

Authors: Bagosi, Z., Czebely-Lenart A., Karasz G., Csabafi K., Jaszberenyi M., Telegdy G.

  Intracerebroventricular corticotropin releasing factor, antalorium, antistressin 2/3 and urocortin 1/2/3 on social interaction in mice
  Bagosi, Z., Czebely-Lenart A., Karasz G., Csabafi K., Jaszberenyi M., Telegdy G. - 2017

  ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   NEUROPEPTIDES
Contained in: Brain Res., 2017: 1663, 114-122

The effects of CRF and urocortins on the sociability of mice

Authors: Bagosi, Z., Karasz G., Czebely-Lenart A., Csabafi K., Jaszberenyi M., Telegdy G.

  Brain corticotropin-releasing factor and urocortins levels on locomotion/exploration and social interaction in mice
  Bagosi, Z., Karasz G., Czebely-Lenart A., Csabafi K., Jaszberenyi M., Telegdy G. - 2017

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   NEUROPEPTIDES
Contained in: Behav. Brain Res., 2017: 326, 121-131

Repeated corticosterone injections in adult mice alter stress hormonal receptor expression in the cerebellum and motor coorcination without affecting spatial learning

Authors: Harlé, G., Lalonde R., Fonte C., Ropars A., Frippiat J.-P., Strazielle C.

  Systemic corticosterone exposure on cerebellar corticotropin-releasing hormone/glucocorticoid receptor expression, locomotion/exploration and spatial learning in mice
  Harlé, G., Lalonde R., Fonte C., Ropars A., Frippiat J.-P., Strazielle C. - 2017

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   CEREBELLUM   SPATIAL ORIENTATION AND SPATIAL MEMORY   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS
Contained in: Psychopharmacology, 2017: 234, 1315-1332

Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction

Authors: Koob, G.F.

  Addiction and motivational disorder animal models - Review
  Koob, G.F. - 2017

  ACETYLCHOLINE   OPERANT CONDITIONING   CORTICO-RELEASING-FACTOR (CRF)   DOPAMINE   OPIOIDS   REVIEWS AND COMMENTARIES
Contained in: Neurosci. Behav. Physiol., 2017: 47, 449-455

Stress-induced changes in corticoliberin and vasopressin expression in the hypothalamus of female rats in a model of post-traumatic stress disorder

Authors: Mironova, V.I., Rakitskaya V.V., Pivina S.G., Ordyan N.E.

  Stress on hypothalamic corticoliberin/vasopressin expression in female rats
  Mironova, V.I., Rakitskaya V.V., Pivina S.G., Ordyan N.E. - 2017

  CORTICO-RELEASING-FACTOR (CRF)   GONADAL HORMONES   HYPOTHALAMUS   STRESS   VASOPRESSIN, VASOTOCIN
Contained in: Psychopharmacology, 2017: 234, 1881-1889

Social setting, social rank and HPA axis response in cynomolgus monkeys

Authors: Jimenez, V.A., Allen D.C., McClintick M.N., Grant K.A.

  Social setting on hypothalamic-pituitary-adrenal axis activity in monkeys: dexamethasone, corticotropin releasing factor and naloxone exposure effects
  Jimenez, V.A., Allen D.C., McClintick M.N., Grant K.A. - 2017

  ADRENO-CORTICO-TROPIC-HORMONE (ACTH)   PITUITARY-ADRENAL AXIS   ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   HYPOTHALAMUS   OPIOIDS   STRESS
Contained in: Neuroscience, 2017: 354, 11-29

Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background

Authors: Farkas, J., Kovacs L.A., Gaspar L., Nafz A., Gaszner T., Ujvari B., Koros V., Csernus V., Hashimoto H., Reglodi D., Gaszner B.

  Maternal deprivation, cheonic stress and pituitary adenylate cyclase activating polypeptide role in dorsal raphe nucleus serotonin, bed nucleus of the stria terminalis corticotropin-releasing factor, Edinger-Westphal nucleus urocortin-1 expressing neurons, blood corticosterone levels, exploratory activity and response to stress in mice
  Farkas, J., Kovacs L.A., Gaspar L., Nafz A., Gaszner T., Ujvari B., Koros V., Csernus V., Hashimoto H., Reglodi D., Gaszner B. - 2017

  EXPLORATORY ACTIVITY   ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   DARK/LIGHT CONTEXT   GLUCOCORTICOIDS   DORSAL AND MEDIAL RAPHE NUCLEI   SEROTONIN   PROTEINS AND GENES   STRESS   VIP, PACAP, EPAC
Contained in: Neuropharmacology, 2017:121, 60-68

CRFR1 in the ventromedial caudate putamen modulates acute stress-enhanced expression of cocaine locomotor sensitization

Authors: Liu, S., Wang Z., Li Y., Sun X., Ge F., Yang M., Wang X., Wang N., Wang J., Cui C.

  Caudatal corticotropin-releasing factor receptor 1 role in stress effects on cocaine-induced locomotor sensitization in rats
  Liu, S., Wang Z., Li Y., Sun X., Ge F., Yang M., Wang X., Wang N., Wang J., Cui C. - 2017

  LOCOMOTOR ACTIVITY   CORTICO-RELEASING-FACTOR (CRF)   DOPAMINE   STRESS   STRIATUM
Contained in: Neuropharmacology, 2017: 122, 100-106

The bed nucleus of the stria terminalis in drug-associated behavior and affect: a circuit-based perspective

Authors: Vranjkovic, O., Pina M., Kash T.L., Winder D.G.

  Bed nucleus of the stria terminalis and derug-associated behavior - Review
  Vranjkovic, O., Pina M., Kash T.L., Winder D.G. - 2017

  EPINEPHRINE AND NOREPINEPHRINE   CORTICO-RELEASING-FACTOR (CRF)   DOPAMINE   γ-AMINO-BUTYRIC ACID (GABA)   GLUTAMATE   NEUROPEPTIDES   REVIEWS AND COMMENTARIES   SEROTONIN   UNSPECIFIC ASCENDING ACTIVATING SYSTEM PROJECTION
Contained in: Behav. Brain Res., 2017: 329, 41-50

The blockage of ventromedial hypothalamus CRF type 2 receptors impairs escape responses in the elevated T-maze

Authors: Silva, M.S.C.F., Souza T.M.O., Pereira B.A., Ribeiro D.A., Cespedes I.C., Bittencourt J.C., Viana M.B.

  Ventromedial hypothalamic corticotropin-re3leasing factor modulation on elevated T-maze exploration in rats
  Silva, M.S.C.F., Souza T.M.O., Pereira B.A., Ribeiro D.A., Cespedes I.C., Bittencourt J.C., Viana M.B. - 2017

  EXPLORATORY ACTIVITY   CORTICO-RELEASING-FACTOR (CRF)   HYPOTHALAMUS
Contained in: Behav. Brain res., 2017: 329, 180-185

The interaction of corticotropin-releasing hormone receptor gene and early life stress on emotional empathy

Authors: Grimm, S., Wirth K., Fan Y., Weigand A., Gartner M., Feeser M., Dziobek I., Bajbouj M., Aust S.

  Early life stress and corticotropin-releasing hormone receptor 1 polymorphism on social cognition in adult humans
  Grimm, S., Wirth K., Fan Y., Weigand A., Gartner M., Feeser M., Dziobek I., Bajbouj M., Aust S. - 2017

  SEXUAL BEHAVIOR   ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   PROTEINS AND GENES   STRESS
Contained in: Neuroscience, 2017: 356, 89-101

Sex differences in the effect of chronic mild stress on mouse prefrontal cortical BDNF levels: a role of major ovarian hormones

Authors: Karisetti, B.C., Joshi P.C., Kumar A., Chakravarty S.

  Chronic mild stress on prefrontal brain-derived neurotrophic factor/corticotropin releasing factor/neuropeptide Y expression, sucrose preference, locomotion, exploration and response to stress in male, ovariectomized and intact female mice
  Karisetti, B.C., Joshi P.C., Kumar A., Chakravarty S. - 2017

  EXPLORATORY ACTIVITY   LOCOMOTOR ACTIVITY   ENVIRONMENT AND SOCIAL BEHAVIOR   CEREBRAL CORTEX   CORTICO-RELEASING-FACTOR (CRF)   GENDER   GLUCOCORTICOIDS   GONADAL HORMONES   NEUROPEPTIDES   NEUROTROPHIC FACTORS   STRESS
Contained in: Trends Neurosci., 2017: 40, 667-679

Stress and seizures: space, time and hippocampal circuits

Authors: Glunn, B.G., Baram T.Z.

  Hippocampus, stress and seizure generation - Review
  Glunn, B.G., Baram T.Z. - 2017

  REVIEWS AND COMMENTARIES   STRESS   HIPPOCAMPUS, FORNIX AND SUBICULUM   GLUCOCORTICOIDS   γ-AMINO-BUTYRIC ACID (GABA)   CORTICO-RELEASING-FACTOR (CRF)
Contained in: Behav. Brain Res., 2017: 335, 32-40

Chronic traumatic stress impairs memory in mice: potential roles of acetylcholine, neuroinflammation and corticotropin releasing factor expression in the hippocampus

Authors: Bhakta, A., Gavini K., Yang E., Lyman-Henley L., Parameshwaran K.

  Predator stress on hippocampal corticotropin releasing hormone, Arc and c-fos expression, acetylcholine, interleukin-1β, nerve growth factor and brain-derived neurotrophic factor levels, exploratory activity, sucrose preference and spatial learning in rodents
  Bhakta, A., Gavini K., Yang E., Lyman-Henley L., Parameshwaran K. - 2017

  ACETYLCHOLINE   EXPLORATORY ACTIVITY   AGGRESSIVE AND DEFENSIVE BEHAVIOR   SPATIAL ORIENTATION AND SPATIAL MEMORY   CORTICO-RELEASING-FACTOR (CRF)   HIPPOCAMPUS, FORNIX AND SUBICULUM   NEUROPEPTIDES   NEUROTROPHIC FACTORS   PROTEINS AND GENES   STRESS
Contained in: Annu. Rev. Psychol., 2017: 68, 215-241

Gene x environment interactions: from molecular mechanisms to behavior

Authors: Halldorsdottir, T., Binder E.B.

  Gene-by-environment interactions and molecular mechanisms under behaviors - Review
  Halldorsdottir, T., Binder E.B. - 2017

  ADRENO-CORTICO-TROPIC-HORMONE (ACTH)   PITUITARY-ADRENAL AXIS   CANNABINOIDS   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   HYPOTHALAMUS   PROTEIN KINASES   REVIEWS AND COMMENTARIES   SEROTONIN   PROTEINS AND GENES   STRESS
Contained in: Pharmacol. Biochem. Behav., 2017: 161, 68-76

Resveratrol ameliorated the behavioral deficits in a mosue model of post-traumatic stress disorder

Authors: Zhang, Z.-S., Qiu Z.-K., He J.-L., Liu X., Chen J.-S., Wang Y.-L.

  Resveratrol and sertaline on response to footshock and related adrenoc-cortico-tropic-hormone, corticotropic releasing hormone and corticosterone serum levels, hippocampal and prefrontal neurosteroids levels and exploratory/rearing activity in mice
  Zhang, Z.-S., Qiu Z.-K., He J.-L., Liu X., Chen J.-S., Wang Y.-L. - 2017

  ADRENO-CORTICO-TROPIC-HORMONE (ACTH)   EXPLORATORY ACTIVITY   CEREBRAL CORTEX   CORTICO-RELEASING-FACTOR (CRF)   FEAR AND RELATED BEHAVIORS   GLUCOCORTICOIDS   GONADAL HORMONES   HIPPOCAMPUS, FORNIX AND SUBICULUM   SEROTONIN   STRESS
Contained in: Psychopharmacology, 2017: 234, 3249-3257

Plasma cortisol response cannot be classically conditioned in a taste-endocrine paradigm in humans

Authors: Petrakova, L., Boy K., Kugler M., Benson S., Emgler H., Moller L., Schedlowski M.

  Corticotropin releasing hormone as unconditioned stimulus in Pavlovian taste conditioning of humans
  Petrakova, L., Boy K., Kugler M., Benson S., Emgler H., Moller L., Schedlowski M. - 2017

  EPINEPHRINE AND NOREPINEPHRINE   CLASSICAL PAVLOVIAN CONDITIONING   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   TASTE
Contained in: Physiol. Behav., 2017: 178, 117-125

Susceptibility or resilience? Prenatal stress predisposes male rats to social subordinatio, but faciitates adaptation to subordinate status

Authors: Scott, K.A., de Kloet A.D., Smeltzer M.D., Krause E.G., Flak J.N., Melhorn S.J., Foster M.T., Tamashiro K.L.K., Sakai R.R.

  Prenatal stress on amygdalar-hypothalamic corticotropin releasing hormone/amygdalar neuropeptide Y expression, exploratory activity, social subordination and related plasma corticosterone/testosterone levels in male rat offspring
  Scott, K.A., de Kloet A.D., Smeltzer M.D., Krause E.G., Flak J.N., Melhorn S.J., Foster M.T., Tamashiro K.L.K., Sakai R.R. - 2017

  AMYGDALA   EXPLORATORY ACTIVITY   ENVIRONMENT AND SOCIAL BEHAVIOR   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   GONADAL HORMONES   HYPOTHALAMUS   NEUROPEPTIDES   STRESS
Contained in: Neuropharmacology, 2017: 125, 418-428

CRF modulates glutamte transmission in the central amygdala of naive and ethanol-dependent rats

Authors: Varodayan, F.P., Correia D., Kirson D., Khom S., Oleata C.S., Luu G., Schweitzer P., Roberto M.

  Corticotrophin releasing factor modulation on central amygdala neuron excitability and glutamatergic transmission in ethanol-dependent and control rats
  Varodayan, F.P., Correia D., Kirson D., Khom S., Oleata C.S., Luu G., Schweitzer P., Roberto M. - 2017

  AMYGDALA   CORTICO-RELEASING-FACTOR (CRF)   GLUTAMATE   ELECTRIC/MAGNETIC CENTRAL NERVOUS SYSTEM STIMULATION
Contained in: Neurosci. Lett., 2017: 661, 11-17

Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia

Authors: Butler, R.K., Ehling S., Barbar M., Thomas J., Hughes M.A., Smith C.E., Pogorelov V.M., Aryal D.K., Wetsel W.C., Lascelles B.D.X.

  Amygdalar calcium-calmodulin kinase II, parvalbumin and corticotrophin releasing factor positive neurons role in conditioned fear by painful stimulation and related conditioned analgesia in mice: c-fos expression study
  Butler, R.K., Ehling S., Barbar M., Thomas J., Hughes M.A., Smith C.E., Pogorelov V.M., Aryal D.K., Wetsel W.C., Lascelles B.D.X. - 2017

  AMYGDALA   LATERALITY AND ASYMMETRICAL INTERVENTIONS   CORTICO-RELEASING-FACTOR (CRF)   FEAR AND RELATED BEHAVIORS   PROTEIN KINASES   PROTEINS AND GENES   NOCICEPTION
Contained in: Physiol. Behav., 2017: 179, 451-457

Up-regulation of GluR1 in paraventricular nucleus and greater expressions of synapse related proteins in the hypothalamus of chronic unpredictable stress-induced depressive rats

Authors: Li, R., Zhao X., Cai L., Gao W.

  Chronic stress on hypothalamic neuron corticotropin releasing hormone-GluR1 expression and synaptic protein levels, serum corticosterone leveles, sucrose preference, response to stress and exploration/grooming/rearing in rats
  Li, R., Zhao X., Cai L., Gao W. - 2017

  EXPLORATORY ACTIVITY   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   GLUTAMATE   STEROTYPED BEHAVIORS   HYPOTHALAMUS   PROTEINS AND GENES   STRESS
Contained in: Plos Biol., 2017: 15, e2002257

Lef1-dependent hypothalamic neurogenesis inhibits anxiety

Authors: Xie, Y., Kaufmann D., Moulton M.J., Panahi S., Gaynes J.A., Watters H.N., Zhou D., Xue H.-H., Fung C.M., Levine E.M., Letsou A., Brennan K.C., Dorsky R.I.

  Lef1 gene on hypothalamic neurogenesis and exploratory activity in zebrafishes and mice: CRHBP and PMCH genes related to corticotropin releasing hormone and melanin from Drosophila to humans study
  Xie, Y., Kaufmann D., Moulton M.J., Panahi S., Gaynes J.A., Watters H.N., Zhou D., Xue H.-H., Fung C.M., Levine E.M., Letsou A., Brennan K.C., Dorsky R.I. - 2017

  EXPLORATORY ACTIVITY   CORTICO-RELEASING-FACTOR (CRF)   HYPOTHALAMUS   MELANOCITE STIMULATING HORMONE (MSH) AND MELANIN   NEUROGENESIS AND PLASTICITY   PROTEINS AND GENES
Contained in: Brain Res. Bull., 2017: 135, 77-84

Crassifoside H improve the depressive-like behavior of rats under chronic unpredictable mild stress: possible involved mechanisms

Authors: Zhang, Y., Ge J.-F., Wang F.-F., Liu F., Shi C., Li N.

  Crassifoside H and fluoxetine exposure on stress effects on hippocampal 5-HT1A receptor, extracellular signal-regulated kinase and brain-derived neurotrophic factor expression, hypothalamic corticotropin releasing factor and plasma corticosterone levels, sucrose preference, response to stress and locomotion/exploration/grooming in rats
  Zhang, Y., Ge J.-F., Wang F.-F., Liu F., Shi C., Li N. - 2017

  EXPLORATORY ACTIVITY   CORTICO-RELEASING-FACTOR (CRF)   GLUCOCORTICOIDS   STEROTYPED BEHAVIORS   HYPOTHALAMUS   HIPPOCAMPUS, FORNIX AND SUBICULUM   NEUROTROPHIC FACTORS   PROTEIN KINASES   SEROTONIN   STRESS
Contained in: Psychopharmacology, 2017: 234, 2813-2821

Prevention and reversal of social stress-escalated cocaine self-administration in mice by intra-VTA CRFR1 antagonism

Authors: Han, X., DeBold J.F., Miczek K.A.

  Systemic or intra-ventral tegmental area corticotrophin releasing factor receptor 1 antagonist on social stress effects on operant cocaine self-administration in mice
  Han, X., DeBold J.F., Miczek K.A. - 2017

  ACETYLCHOLINE   ENVIRONMENT AND SOCIAL BEHAVIOR   OPERANT CONDITIONING   CORTICO-RELEASING-FACTOR (CRF)   DOPAMINE   UNSPECIFIC ASCENDING ACTIVATING SYSTEM PROJECTION   STRESS