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2018
Pistacia lentiscus oil attenuates memory dysfunction and decreases levels of biomarkers of oxidative stress induced by lipopolysaccharide in rats
Authors: Ammari, M., Othman H., Hajri A., Sakly M., Abdelmelek H. Pistocia lentiscus oil on lipopolisaccharide exposure effects on brain neuronal oxidative stress, acetyl/butyrilcholinesterase levels and object location/recognition performance in rats
Ammari, M., Othman H., Hajri A., Sakly M., Abdelmelek H. - 2018
Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in hippocampus in vivo and in vitro
Authors: Shen, J., Xu L., Qu C., Sun H., Zhang J. Resveratrol exposure on chronic mild stress effects on hippocampal CREB/brain-derived neurotrophic factor expression and Morris water maze performance in rats
Shen, J., Xu L., Qu C., Sun H., Zhang J. - 2018
Ginsenoside Rh2 reverses sleep deprivation-induced cognitive deficit in mice
Authors: Lu, C., Wang Y., Lv J., Jiang N., Fan B., Qu L., Li Y., Chen S., Wang F., Liu X. Ginsenoside Rh2 and modafinil on sleep deprivation effects on hippocampal/cortical neruon oxidative stress, locomotion. exploration, passive avoidance and object/location recognition in mice
Lu, C., Wang Y., Lv J., Jiang N., Fan B., Qu L., Li Y., Chen S., Wang F., Liu X. - 2018
The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment
Authors: Borghans, L.G.J.M., Sambeth A., Prickaerts J., Ramaekers J.G., Blokland A. Soluble guanylate cyclase stimulation on learning and memory in humans
Borghans, L.G.J.M., Sambeth A., Prickaerts J., Ramaekers J.G., Blokland A. - 2018
The memory-enhancing effects of 7,8,4'-trihydroxyisoflavone, a major metbolite of daidzein, are associated with activation of the cholinergic system and BDNF signbaling pathway in mice
Authors: Ko, Y.-H., Kwon S.-H., Ma S.-X., Seo J.-Y., Lee B.-R., Kim K., Kim S.Y., Lee S.-Y., Jang C.-G. Daidzein isoflavone metabolite on hippocampal brain-derived neurotrophic factor/CREB/extracellular-signal regulated kinase expression, nociception, spatial learning, passive avoidance and scopolamine-induced cognitive and cholinergic system deficit in mice
Ko, Y.-H., Kwon S.-H., Ma S.-X., Seo J.-Y., Lee B.-R., Kim K., Kim S.Y., Lee S.-Y., Jang C.-G. - 2018
Dietary choline supplementation in adult rats improves performance on a test of recognition memory
Authors: Moreno, H., Hall G., Gallo M., de Brugada I. Choline supplementation on object recognition performance in rats
Moreno, H., Hall G., Gallo M., de Brugada I. - 2018
5-HT6 receptor agonist and memory-enhancing properties of hypidone hydrochloride (YL-0919), a novel 5-HT1A receptor partial agonist and SSRI
Authors: Chen, X., Jin Z., Gong Y., Zhao N., Wang X., Ran Y., Zhang Y., Zhang L., Li Y.-F.
5-HT6 agonist on object recognition, passive avoidance and Morris water maze perfomance in rodents
Chen, X., Jin Z., Gong Y., Zhao N., Wang X., Ran Y., Zhang Y., Zhang L., Li Y.-F. - 2018
Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease
Authors: Gulisano W., Tropea M.R., Arancio O., Palmeri A., Puzzo D. Phosphodiesterase 4/5 inhibitors on novel object recognition, fear conditioning and Morris water maze performance in APP mice
Gulisano W., Tropea M.R., Arancio O., Palmeri A., Puzzo D. - 2018
Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation
Authors: Ratano, P., Petrella C., Forti F., Petrocchi Passeri P., Morena M., Palmery M., Trezza V., Severini C., Campolongo P. Post-training monoacylglycerol lipase inhibitor on hippocampal/amygdalar mTOR/CB2 receptor signaling and passive avoidance consolidation in rats
Ratano, P., Petrella C., Forti F., Petrocchi Passeri P., Morena M., Palmery M., Trezza V., Severini C., Campolongo P. - 2018
Synaptic modification by L-theanine, a natural constituent in green tea, rescues the impairment of hippocampal long-term potentiation and memory in AD mice
Authors: Zhu, G., Yang S., Xie Z., Wan X. L-theamine on hippocampal neuron excitability, dopamine/norepinephrine/protein kinase A phosphorylation levels and fear conditioning performance in APP/PS1 and control mice
Zhu, G., Yang S., Xie Z., Wan X. - 2018
Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion
Authors: Santiago A., Soares L.M., Schepers M., Milani H., Vanmierlo T., Prickaerts J., de Oliveira R.M.W. Phosphodiesterase type 4 inhibitor roflumilast exposure on chronic cerebral hypoperfusion effects on white matter injury, hippocampal neuroinflammation, CREB-brain-derived neurotrophic factor expression and spatial navigation in aged rats
Santiago A., Soares L.M., Schepers M., Milani H., Vanmierlo T., Prickaerts J., de Oliveira R.M.W. - 2018
2017
Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat brain
Authors: Ruchel, J.B., Braun J.B.S., Adefegha S.A., Manzoni A.G., Abdalla F.H., de Oliveira J.S., Trelles K., Signor C., Lopes S.T.A., da Silva C.B., Castilhos L.G., Rubin M.A., Leal D.B.R. Guarana, caffeine and simvastatin on hyperlipidemia-induced effects on brain acetylcholinesterase activity, exploratory activity and object recognition performance in rats
Ruchel, J.B., Braun J.B.S., Adefegha S.A., Manzoni A.G., Abdalla F.H., de Oliveira J.S., Trelles K., Signor C., Lopes S.T.A., da Silva C.B., Castilhos L.G., Rubin M.A., Leal D.B.R. - 2017
Late treatment with choline alfoscerate (L-Alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal Death and cognitive impairment
Authors: Lee, S.H., Choi B.Y., Kim J.H., Kho A.R., Sohn M., Song H.K., Choi H.C., Suh S.W. Choline alfoscerate on hippocampal neurogenesis and seizure pilocarpine-induced hippocampal neuronal loss, choline acetyltrasnferase activity and Morris water maze impairment in rats
Lee, S.H., Choi B.Y., Kim J.H., Kho A.R., Sohn M., Song H.K., Choi H.C., Suh S.W. - 2017
The olfactory bulbectomized rat as a model od depression: the hippocampal pathway
Authors: Morales- Medina, J.C., Iannitti T., Freeman A., Caldwell H.K. Olfactory bulbectomy as rat model of depression: locomotion, hippocampal neurogenesis, plasticity, long-term potentiation, response to antidepressants and nootropics
Morales- Medina, J.C., Iannitti T., Freeman A., Caldwell H.K. - 2017
Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL/6 mice: the case of chlorpyrifos and rivastigmine
Authors: Basaure, P., Peris-Sampedro F., Cabré M., Reverte I., Colomina M.T. Chlorpyrifos and rivastigmine, acetylcholinestearse inhibitors, on exploratory activity and spatial learning in mice
Basaure, P., Peris-Sampedro F., Cabré M., Reverte I., Colomina M.T. - 2017
Reducing falls in a model of impaired cognitive control of movement (Commentary on Kucinski et al.)
Authors: Burk, J.A. Acetylcholinesterase inhibitor and 5-HT6 antagonist on impaired cognitive control of movement - Commentary
Burk, J.A. - 2017
Reducing falls in Parkinson's disease: interactions between donepezil and the 5-HT6 receptor antagonist idalopiridine on falls in a rat model of impaired cognitive control of complex movements
Authors: Kucinski, A., de Jong I.E.M., Sarter M. Acetylcholinesterase inhibitor donepezil and 5-HT6 antagonist idalopiridine on striatal dopaminergic and nucleus basalis magnocellularis cholinergic lesions effects on operant rewarded sustained attention task performance in rats
Kucinski, A., de Jong I.E.M., Sarter M. - 2017
α-Isocubebenol alleviates scopolamine-induced cognitive impairment by repressing acetylcholinesterase activity
Authors: Song, S.H., Choi S.M., Kim J.E., Sung J.E., Lee H.A., Choi Y.H., Bae C.J., Choi Y.W., Hwang D.Y. α-Isocubebenol on scopolamine-induced hippocampal acetylcholinesterase activity, extracellular signal-regulated kinase phosphorylation, neuronal cell survival and passive avoidance impairment in mice
Song, S.H., Choi S.M., Kim J.E., Sung J.E., Lee H.A., Choi Y.H., Bae C.J., Choi Y.W., Hwang D.Y. - 2017
Portulaca oleracea L. prevents lipopolysaccharide-induced passive avoidance learning and memory and TNF-α impairments in hippocampus of rat
Authors: Noorbakhshnia, M., Karimi-Zandi L. Portulaca oleracea L. hydro-alcoholic extract on lipopolysaccharide effects on passive avoidance and hippocampal tumor necrosis factor-α levels in rats
Noorbakhshnia, M., Karimi-Zandi L. - 2017
Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms
Authors: Li, M., Li H., Fang F., Deng X., Ma S. Astragaloside IV on cerebral ischemia-induced hippocampal neuron inflammation, microglia activation and Morris water maze cognitive impairment in mice
Li, M., Li H., Fang F., Deng X., Ma S. - 2017
Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats
Authors: Kougias, D.G., Hankosky E.R., Gulley J.M., Juraska J.M. Beta-hydroxy-beta-methylbutyrate on spatial learning in middle aged and aged male and female rats
Kougias, D.G., Hankosky E.R., Gulley J.M., Juraska J.M. - 2017
Calcineurin inhibitors improve memory loss an neuropathological changes in mouse model of dementia
Authors: Kumar, A., Singh N. Calcineurin inhibitors on intracerebroventricular streptozotocin-induced brain acetylcholinesterase, nitric oxide, neuroinflammation changes and spatial learning impairment in young and aged mice
Kumar, A., Singh N. - 2017
Oleanolic acid ameliorates cognitive dysfunction caused by cholinergic blockade via TrkB-dependent BDNF signaling
Authors: Jeon, S.J., Lee H.J., Lee H.E., Park S.J., Gwon Y., Kim H., Zhang J., Shin C.Y., Kim D.H., Ryu J.H. Oleanolic acid triterpenoid on scopoalmine-induced hippocampal neuron excitability, spatial learning, passive avoidance and object recognition impairment via brain-derived neurotrophic factor/extracellular signal-regulated kinase 1/2/CREB signaling in mice
Jeon, S.J., Lee H.J., Lee H.E., Park S.J., Gwon Y., Kim H., Zhang J., Shin C.Y., Kim D.H., Ryu J.H. - 2017
Neuroprotective effects of sildenafil against oxidative stress and memory dysfunction in mice exposed to noise stress
Authors: Sikandaner, H.E., Park S.Y., Kim M.J., Park S.N., Yang D.W. Sildenafil on stress-induced hippocampal oxidative stress, brain-derived neurotrophic factor, CREB norepinephrine and serotonin levels, object recognition and spatial learning impairment in mice
Sikandaner, H.E., Park S.Y., Kim M.J., Park S.N., Yang D.W. - 2017
Resveratrol ameliorates spatial learning memory impairment induced by Aβ1-42 in rats
Authors: Wang, R., Zheng Y., Li J., Zhang C. Resveratrol on intra-hippocampal amyloid β1-42-induced hippocampal neuron excitability and Morris water maze performance impairment in rats: CREB phosphorylation study
Wang, R., Zheng Y., Li J., Zhang C. - 2017
Astaxanthin improves cognitive performance in mice following mild traumatic brain injury
Authors: Ji, X., Peng D., Zhang Y., Zhang J., Wang Y., Gao Y., Lu N., Tang P. Astaxanthin on brain injury effects on cortical synaptic proteins/brain-derived neurotrophic factor levels, locomotion, spatial learning and object recognition in mice
Ji, X., Peng D., Zhang Y., Zhang J., Wang Y., Gao Y., Lu N., Tang P. - 2017
A unique combination of micronutrients rejuvenates cognitive performance in aged mice
Authors: Perez, S.D., Du K., Rendeiro C., Wang L., Wu Q., Rubakhin S.S., Vazhappilly R., Baxter J.H., Sweedler J.V., Rhodes J.S. Micronutrients combination on feeding, hippocampal neurogenesis/neuroinflammation/metabolites levels and active avoidance in young and aged male and female mice
Perez, S.D., Du K., Rendeiro C., Wang L., Wu Q., Rubakhin S.S., Vazhappilly R., Baxter J.H., Sweedler J.V., Rhodes J.S. - 2017
Loganin enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments
Authors: Hwang, E.-S., Kim H.-B., Lee S., Kim M.-J., Lee S.-O., Han S.-M., Maeng S., Park J.-H. Loganin on hippocampal neurons excitability and scopolamine-induced passive avoidance and spatial learning impairment in rats
Hwang, E.-S., Kim H.-B., Lee S., Kim M.-J., Lee S.-O., Han S.-M., Maeng S., Park J.-H. - 2017
The novel dehydroepiansdrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats
Authors: Pitsikas, N., Gravanis A. Neurosteroid BNN27 on object location/recognition performance in scopolamine exposed and control rats
Pitsikas, N., Gravanis A. - 2017
Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis
Authors: Beckervordersandforth, R., Ebert B., Schaffner I., Moss J., Fiebig C., Shin J., Moore D.L., Ghosh L., Trinchero M.F., Stockburger C., Friedland K., Steib K., von Wittgenstein J., Keiner S., Redecker C., Holter S.M., Xiang W., Wurst W., Jagasia R., Schinder A.F., Ming G., Toni N., Jessberger S., Song H., Lie C. Mitochondrial metabolism on hippocampal adult neurogenesis and plasticity in mice of different age
Beckervordersandforth, R., Ebert B., Schaffner I., Moss J., Fiebig C., Shin J., Moore D.L., Ghosh L., Trinchero M.F., Stockburger C., Friedland K., Steib K., von Wittgenstein J., Keiner S., Redecker C., Holter S.M., Xiang W., Wurst W., Jagasia R., Schinder A.F., Ming G., Toni N., Jessberger S., Song H., Lie C. - 2017