Themes: NOOTROPICS

2014

Contained in: Pharmacol. Biochem. Behav., 2014: 127, 42-48

Ro 04-6790-induced cognitive enhancement: no effect in trace conditioning and novel object recognition procedures in adult male Wistar rats

Authors: Thur, K.E., Nelson A.J.D., Cassaday H.J.

  5-HT6 antagonist on conditioned suppression and object recognition in rats
  Thur, K.E., Nelson A.J.D., Cassaday H.J. - 2014

  CONDITIONED AND UNCONDITIONED INHIBITION   NOOTROPICS   SEROTONIN
Contained in: NeuroReport, 2014: 25, 647-650

Quetiapine attenuates recognition memory impairment and hippocampal oxidative stress in a transgenic mouse model of Alzheimer’s disease

Authors: Luo, G., Liu M., He J., Guo H., Xue M., Wang X., Li X.-M.

  Quetiapine on object recognition and hippocampal oxidative stress in conrol and APP Alzheimer's disease mice
  Luo, G., Liu M., He J., Guo H., Xue M., Wang X., Li X.-M. - 2014

  HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS
Contained in: Neurobiol. Learn. Mem., 2014: 109,<u> </u>139-143

Mind the gap: delayed manifestation of long-term object rnemory improvement by phosphodiesterase inhibitors

Authors: Akkerman, S., Blokland A., Prickaerts J.

  Rolipram and vardenofil on object recognition memory in rats
  Akkerman, S., Blokland A., Prickaerts J. - 2014

  NOOTROPICS   CONSOLIDATION

2013

Contained in: Neuroscience, 2013: 236, 281-288

Icariin promotes histone acetylation and attenuates post-stroke cognitive impairment in the central cholinergic circuits of mice

Authors: Wang, X., Li J., Qian L., Zang X.-F., Zhang S.-Y., Wang X.-Y., Jin J.-L., Zhu X.-L., Zhang X.-B., Wang Z.-Y., Xu Y.

  Flavonoid icariin on spatial learning, histone acetylation, CREB expression and central cholinergic circuit activation in mice: post-stroke effects
  Wang, X., Li J., Qian L., Zang X.-F., Zhang S.-Y., Wang X.-Y., Jin J.-L., Zhu X.-L., Zhang X.-B., Wang Z.-Y., Xu Y. - 2013

  ACETYLCHOLINE   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS   NUCLEUS BASALIS MAGNOCELLULARIS   PROTEINS AND GENES
Contained in: Behav. Brain Res., 2013: 244, 70-81

Salidroside attenuates beta amyloid-induced cognitive deficits via modulation oxidative stress and inflammatory mediators in rat hippocampus

Authors: Zhang, J., Zhen Y., Pu-Bu-Ci-Ren, Song L., Kong W., Shao T., Li X., Chai X.

  Salidroside effect on intrahippocampal &beta;-amyloid-induced cognitive and biochemical damage in rats
  Zhang, J., Zhen Y., Pu-Bu-Ci-Ren, Song L., Kong W., Shao T., Li X., Chai X. - 2013

  ACETYLCHOLINE   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   NITRIC AND NITROUS OXIDE   NOOTROPICS
Contained in: Pharmacol. Biochem. Behav., 2013: 105, 41-50

Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

Authors: Mork, A., Montezinho L.P., Miller S., Trippodi-Mutphy C., Plath N., Li Y., Gulinello M., Sanchez C.

  Vortioxetine on object recognition, fear conditioning acquisition and consolidation, pain sensitivity, prefrontal acetylcholine and histamine release in the rat
  Mork, A., Montezinho L.P., Miller S., Trippodi-Mutphy C., Plath N., Li Y., Gulinello M., Sanchez C. - 2013

  ACETYLCHOLINE   CEREBRAL CORTEX   FEAR AND RELATED BEHAVIORS   HISTAMINE   NOOTROPICS   SEROTONIN   NOCICEPTION   CONSOLIDATION
Contained in: Neurosci. Lett., 2013: 543, 115-120

Xanthoceraside attenuates learning and memory derficits via improving insulin signaling in STZ-induced AD rats

Authors: Liu, P., Zhou L., Jiao Q., Chi T., Ji X., Qi Y., Xu Q., Wang L.

  Memantine, donepezil and xanthoceraside on cognitive and biochemical damages by intracerebroventricular streptozotocin in rats
  Liu, P., Zhou L., Jiao Q., Chi T., Ji X., Qi Y., Xu Q., Wang L. - 2013

  ACETYLCHOLINE   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS   PROTEIN KINASES   PROTEINS AND GENES
Contained in: Behav. Brain Res., 2013: 246, 111-115

Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice

Authors: Huang, J., Wang C., Wang X., Wu B., Gu X., Liu W., Gong L., Xiao P., Li C.

  Oral tenuigenin on hippocampal excitability, acetylcholinesterase levels and Y-maze avoidance task in mice
  Huang, J., Wang C., Wang X., Wu B., Gu X., Liu W., Gong L., Xiao P., Li C. - 2013

  ACETYLCHOLINE   AVOIDANCE   SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   NOOTROPICS   ELECTRIC/MAGNETIC CENTRAL NERVOUS SYSTEM STIMULATION
Contained in: Behav. Brain Res., 2013: 247, 241-247

p,p1-methoxyl-diphenyl diselenide protects against amyloid-β induced cytotoxicity in vitro and improves memory deficits in vivo

Authors: Pinton, S., Souza A.C., Sari M.H.M., Ramalho R.M., Rodrigues C.M.P., Nogueira C.W.

  p,p1-methoxyl-diphenyl diselenide on amyloid-&beta; cortical apoptosis and spatial learning in rats
  Pinton, S., Souza A.C., Sari M.H.M., Ramalho R.M., Rodrigues C.M.P., Nogueira C.W. - 2013

  ACETYLCHOLINE   CENTRAL NERVOUS SYSTEM LESIONS   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   NOOTROPICS
Contained in: Pharmacol. Biochem. Behav., 2013: 106, 68-76

Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats

Authors: Klusa, V., Muceniece R., Isajevs S., Isajeva D., Beitnere U., Mandrika I., Pupure J., Rumaks J., Jansone B., Kalvinsh I., Vinters H.V.

  Mildronate on passive and active avoidance, hippocampal plasticity, glutamate, acetylcholine, GAP-43 protein and c-jun/AP-1 expression in rats
  Klusa, V., Muceniece R., Isajevs S., Isajeva D., Beitnere U., Mandrika I., Pupure J., Rumaks J., Jansone B., Kalvinsh I., Vinters H.V. - 2013

  ACETYLCHOLINE   AVOIDANCE   GLUTAMATE   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS   NEUROGENESIS AND PLASTICITY   PROTEINS AND GENES
Contained in: Neurosci. Lett., 2013: 553, 138-141

Paradox effects of kynurenines on LTP induction in the Wistar rat. An in vivo study

Authors: Demeter, I., Nagy K., Farkas T., Kis Zs., Kocsis K., Knapp L., Gellert L., Fulop F., Vecsei L., Toldi J.

  Kynurenines on hippocampal long-term potentiation in rats
  Demeter, I., Nagy K., Farkas T., Kis Zs., Kocsis K., Knapp L., Gellert L., Fulop F., Vecsei L., Toldi J. - 2013

  ACETYLCHOLINE   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   N-METHYL-D-ASPARTATE (NMDA)   NOOTROPICS
Contained in: Proc. Natl. Acad. Sci. USA, 2013: 110, E4369-E4374

Human genome-guided identification of memory-modulating drugs

Authors: Papassotiropoulos, A., Gerhards C., Heck A., Ackermann S., Aerni A., Schicktanza N., Auschra N., Demougin P., Mumme E., Elbert T., Ertl V., Gschwind L., Hanser E., Huynh K.-D., Jessen F., Kolassa I.-T., Milnik A., Pagnetti P., Spalek K., Vogler C., Muhs A., Pfeifer A., de Quervain D.J.-F.

  Human genome-guided identification of memory-modulating drugs
  Papassotiropoulos, A., Gerhards C., Heck A., Ackermann S., Aerni A., Schicktanza N., Auschra N., Demougin P., Mumme E., Elbert T., Ertl V., Gschwind L., Hanser E., Huynh K.-D., Jessen F., Kolassa I.-T., Milnik A., Pagnetti P., Spalek K., Vogler C., Muhs A., Pfeifer A., de Quervain D.J.-F. - 2013

  ACETYLCHOLINE   HISTAMINE   OPIOIDS   NOOTROPICS   PROTEINS AND GENES
Contained in: Brain Res., 2013: 1503, 24-32

Protective effect of L-theanine on chronic restraint stress-induced cognitive impairments in mice

Authors: Tian, X., Sun L., Gou L., Ling X., Wang L., Yin X., Liu Y.

  L-theanine on brain dopamine, noradrenaline and antioxidant levels, response to stress and related cognitive impairment in mice
  Tian, X., Sun L., Gou L., Ling X., Wang L., Yin X., Liu Y. - 2013

  EPINEPHRINE AND NOREPINEPHRINE   AVOIDANCE   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   DOPAMINE   GLUCOCORTICOIDS   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS   STRESS
Contained in: Pharmacol. Biochem. Behav., 2013: 105, 134-141

Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice

Authors: Wang, H.-M., Wang L.-W., Liu X.-M., Li C.-L., Xu S.-P., Farooq A.-D.

  Forsythiaside on Morris water maze performance, cortical interleukin, nitric oxide and oxidative stress, hippocampal norepinephrine, dopamine, serotonin, GABA, glutamate and acetylcholine in SAMP1 and SAMP8 mice of different age
  Wang, H.-M., Wang L.-W., Liu X.-M., Li C.-L., Xu S.-P., Farooq A.-D. - 2013

  EPINEPHRINE AND NOREPINEPHRINE   ACETYLCHOLINE   EXPLORATORY ACTIVITY   AVOIDANCE   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   STRAIN   AGE   DOPAMINE   γ-AMINO-BUTYRIC ACID (GABA)   GLUTAMATE   HIPPOCAMPUS, FORNIX AND SUBICULUM   NEUROPEPTIDES   NITRIC AND NITROUS OXIDE   NOOTROPICS   SEROTONIN
Contained in: Neuroscience, 2013: 235, 70-86

Long-term treatment with standardized extract of Ginkgo biloba L. enhances the conditioned suppression of licking in rats by the modulation of neuronal and glia cell function in the dorsal hippocampus and central amygdala

Authors: Oliveira, D.R., Sanada P.F., Filho A.C.S., Conceicao G.M.S., Cerutti J.M., Cerutti S.M.

  Ginkgo biloba extract on fear conditioning, conditioned suppression and related prefrontal, hippocampal and amygdalar CREB expression in rats
  Oliveira, D.R., Sanada P.F., Filho A.C.S., Conceicao G.M.S., Cerutti J.M., Cerutti S.M. - 2013

  AMYGDALA   CEREBRAL CORTEX   FEAR AND RELATED BEHAVIORS   CONDITIONED AND UNCONDITIONED INHIBITION   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS   PROTEINS AND GENES
Contained in: Neuroscience, 2013: 234, 116-124

Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats

Authors: Rushaidhi, M., Zhang H., Liu I.

  Agmatine on exploratory activity, object recognition, Morris water maze performance and hippocampal and prefrontal nitric oxide synthase in young and aged rats
  Rushaidhi, M., Zhang H., Liu I. - 2013

  EXPLORATORY ACTIVITY   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   HIPPOCAMPUS, FORNIX AND SUBICULUM   NITRIC AND NITROUS OXIDE   NOOTROPICS
Contained in: Brain Res. Bull., 2013: 95, 1-6

Preventive effect of theanine intake on stress-induced impairments of hippocampal long-term potentiation and recognition memory

Authors: Tamano, H., Fukura K., Suzuki M., Sakamoto K., Yokogoshi H., Takeda A.

  Theonine and hippocampal long-term potentiation, exploration and recognition memory in stressed and unstressed rats
  Tamano, H., Fukura K., Suzuki M., Sakamoto K., Yokogoshi H., Takeda A. - 2013

  EXPLORATORY ACTIVITY   GLUCOCORTICOIDS   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   NOOTROPICS   STRESS
Contained in: Behav. Brain Res., 2013: 253, 103-112

Repeated and chronic administration of vardenafil or sildenafil differentially affects emotional and socio-sexual behavior in mice

Authors: Dadomo, H., Parmigiani S., Nicolini Y., Freshini S., Gioiosa L., Patrelli T.S., Palanza P., Volpi R.

  Vardenafil and sildenafil effects on aggressive, social, sexual and exploratory behavior in male mice
  Dadomo, H., Parmigiani S., Nicolini Y., Freshini S., Gioiosa L., Patrelli T.S., Palanza P., Volpi R. - 2013

  EXPLORATORY ACTIVITY   AGGRESSIVE AND DEFENSIVE BEHAVIOR   SEXUAL BEHAVIOR   ENVIRONMENT AND SOCIAL BEHAVIOR   NOOTROPICS
Contained in: Physiol. Behav., 2013: 118, 112-117

Tenuigenin ameliorates learning and memory impairments induced by ovariectomy

Authors: Cai, Z.-L., Wang C.-Y., Gu X.-Y., Wang N.J., Wang J.-J., Liu W.-X., Xiao P., Li C.-H.

  Tenuigenin on passive avoidance, hippocampal plasticity and nitric oxide synthase neuron expression in ovariectomized rats
  Cai, Z.-L., Wang C.-Y., Gu X.-Y., Wang N.J., Wang J.-J., Liu W.-X., Xiao P., Li C.-H. - 2013

  AVOIDANCE   GONADAL HORMONES   HIPPOCAMPUS, FORNIX AND SUBICULUM   NITRIC AND NITROUS OXIDE   NOOTROPICS   NEUROGENESIS AND PLASTICITY
Contained in: Pharmacol. Biochem. Behav., 2013: 111, 90-96

Gallic acid prevents memory deficits and oxidative stress induced by intracerebroventricular injection of streptozotocin in rats

Authors: Mansouri, M.T., Naghizadeh B., Ghorbanzadeh B., Farbood Y., Sarkaki A., Bavarsad K.

  Gallic acid on intracerebroventricular streptozotocin-induced oxidative stress and cognitive impairment in rats
  Mansouri, M.T., Naghizadeh B., Ghorbanzadeh B., Farbood Y., Sarkaki A., Bavarsad K. - 2013

  AVOIDANCE   NOOTROPICS
Contained in: Behav. Brain Res., 2013: 258, 8-18

Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice

Authors: Lin, N., Pan X.D., Chen A.Q., Zhu Y.G., Wu M., Zhang J., Chen X.C.

  Tripchlorolide on spatial learning, dark-light box avoidance, hippocampal long-term potentiation, brain derived neurotrophic factor, calcium-calmodulin kinase II, CREB and NMDA receptor expression in SAMP8 mice
  Lin, N., Pan X.D., Chen A.Q., Zhu Y.G., Wu M., Zhang J., Chen X.C. - 2014

  AVOIDANCE   SPATIAL ORIENTATION AND SPATIAL MEMORY   DARK/LIGHT CONTEXT   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   NEUROTROPHIC FACTORS   N-METHYL-D-ASPARTATE (NMDA)   NOOTROPICS   PROTEIN KINASES   PROTEINS AND GENES
Contained in: Behav. Brain Res., 2013: 237, 190-199

L-type calcium channel blockade alleviates molecular and reversal spatial learning and memory alterations induced by entorhinal amyloid pathology in rats

Authors: Gholamipour-Badie, H., Naderi N., Khodagholi F., Shaerzadeh F., Motamedi F.

  Intracerebroventricular calcium channel blockers on &beta;-amyloid nethorhinal lesions spatial learning impairment in rats
  Gholamipour-Badie, H., Naderi N., Khodagholi F., Shaerzadeh F., Motamedi F. - 2013

  CENTRAL NERVOUS SYSTEM LESIONS   SPATIAL ORIENTATION AND SPATIAL MEMORY   ENTORHINAL CORTEX   NOOTROPICS
Contained in: Pharmacol. Biochem. Behav., 2013: 106, 77-84

Protective effects of bilobalide on Aβ25-35 induced learning and memory impairments in male rats

Authors: Yin, Y., Ren Y., Wu W., Wang Y., Cao M., Zhu Z., Wang M., Li W.

  Bilobalide on Morris water maze impairment and neuronal oxidative stress by systemic nimodipine or intra-hippocampal A&beta;25-35 in rats
  Yin, Y., Ren Y., Wu W., Wang Y., Cao M., Zhu Z., Wang M., Li W. - 2013

  CENTRAL NERVOUS SYSTEM LESIONS   SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS
Contained in: Behav. Brain Res., 2013: 236, 16-22

Inhibition of phosphodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

Authors: Reneerkens, O.A.H., Rutten K., Bollen L., Hage T., Blokland A., Steinbusch H.W.M., Prickaerts J.

  Phosphodiesterase type 2 and 10 inhibition on object recognition impairment by scopolamine and MK-801 in aged rats
  Reneerkens, O.A.H., Rutten K., Bollen L., Hage T., Blokland A., Steinbusch H.W.M., Prickaerts J. - 2013

  ACETYLCHOLINE   N-METHYL-D-ASPARTATE (NMDA)   NOOTROPICS
Contained in: Behav. Brain Res., 2013: 253, 212-216

Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

Authors: Wu, W., Yu X., Luo X.-P., Yang S.-H., Zheng D.

  Tetramethylpyrazine on scopolamine-induced Morris water maze performance impairment in rats via AMP/protein kinase A/CREB pathway
  Wu, W., Yu X., Luo X.-P., Yang S.-H., Zheng D. - 2013

  ACETYLCHOLINE   NOOTROPICS   PROTEIN KINASES   PROTEINS AND GENES
Contained in: Neurosci. Lett., 2013: 534, 285-288

Protective effect of cyaniding 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats

Authors: Qin, L., Zhang J., Qin M.

  Cyaniding 3-O-glucoside on intra-hippocampal beta-amyloid peptide-induced spatial learning impairment in rats
  Qin, L., Zhang J., Qin M. - 2013

  SPATIAL ORIENTATION AND SPATIAL MEMORY   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS
Contained in: Behav. Brain Res., 2013: 240, 11-20

Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory

Authors: Palmeri, A., Privitera L., Giunta S., Loreto C., Puzzo D.

  Sildenofil on hippocampal long-term potentiation and CREB expression, spatial learning and object recognition in young and aged mice
  Palmeri, A., Privitera L., Giunta S., Loreto C., Puzzo D. - 2013

  SPATIAL ORIENTATION AND SPATIAL MEMORY   AGE   HIPPOCAMPUS, FORNIX AND SUBICULUM   SHORT- AND LONG-TERM POTENTIATION AND DEPRESSION   NOOTROPICS   PROTEINS AND GENES
Contained in: Pharmacol. Biochem. Behav., 2013: 105, 76-82

Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice

Authors: Sun, C.Y., Qi S.S., Zhou P., Cui H.R., Chen SX., Dai K.Y., Tang M.L.

  Oral curcumin on spatial learning, hippocampal oxidative stress, valcium calmodulin kinase II and NMDA receptor expression in SAMP1 and SAMP8 mice
  Sun, C.Y., Qi S.S., Zhou P., Cui H.R., Chen SX., Dai K.Y., Tang M.L. - 2013

  SPATIAL ORIENTATION AND SPATIAL MEMORY   STRAIN   HIPPOCAMPUS, FORNIX AND SUBICULUM   N-METHYL-D-ASPARTATE (NMDA)   NOOTROPICS   PROTEIN KINASES
Contained in: Neurosci. Lett., 2013: 541, 155-160

Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats

Authors: Zhao, W., Xu S., Peng Y., Ji X., Cao D., Li J., Liu B., Shi Q., Wang L., Wang X.

  Potassium 2-(1-hydroxypentyl)-benzoate on chronic cerebral ischemia cognitive and biochemical damage in rats
  Zhao, W., Xu S., Peng Y., Ji X., Cao D., Li J., Liu B., Shi Q., Wang L., Wang X. - 2013

  SPATIAL ORIENTATION AND SPATIAL MEMORY   CEREBRAL CORTEX   HIPPOCAMPUS, FORNIX AND SUBICULUM   NOOTROPICS
Contained in: Behav. Brain Res., 2013: 257, 8-12

7,8-dihydroxyflavone improves memory consolidation processes in rats and mice

Authors: Bollen, E., Vanmierlo T., Akkerman S., Wouters C., Steinbuschand H.M.W., Prickaerts J.

  7,8-dihydroxyflavone on object location and recognition consolidation in mice and rats
  Bollen, E., Vanmierlo T., Akkerman S., Wouters C., Steinbuschand H.M.W., Prickaerts J. - 2013

  SPATIAL ORIENTATION AND SPATIAL MEMORY   NEUROTROPHIC FACTORS   NOOTROPICS   CONSOLIDATION